Inhibition of IgG-, F(ab')2- and myeloma protein-induced erythrocyte aggregation, by small IgG-fragments

Kazuhiko Imaizumi, Atsuko Imai, Tohru Maruyama, Takeshi Shiga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The velocity of non-immune erythrocyte aggregation was determined by means of an automated rheoscope, consisted of an inverted microscope, a cone-plate viscometer, a TV image analyzer and a computer, in autologous plasma at a shear rate of 7.5/sec. As increasing the concentration of IgG and F(ab')2 added to diluted plasma, the velocity of aggregation increased, resembling the accelerated aggregation in 5 cases of multiple myeloma. Fab- and Fc-fragments scarcely affected the velocity; on contrary, they inhibited the aggregation induced by IgG or F(ab')2 as well as in multiple myeloma. As a plausible explanation of such inhibition, a competitive mechanism is suggested.

Original languageEnglish
Pages (from-to)431-439
Number of pages9
JournalClinical Hemorheology
Volume4
Issue number4
Publication statusPublished - 1984
Externally publishedYes

Keywords

  • Erythrocyte Aggregation
  • IgG-fragments
  • Immunoglobulin
  • Multiple Myeloma

ASJC Scopus subject areas

  • Hematology
  • Physiology

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