Inhibition of thyroxine-induced resorption of tadpole tail by adenosine 3',5'-cyclic monophosphate

K. Yamamoto, S. Kikuyama, I. Yasumasu

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Small segments of tail of Bufo bufo japonicus tadpoles were cultured in medium containing thyroxine (T4) and dibutyryl cyclic AMP (dbcAMP). Like prolactin, the cyclic nycleotide blocked T4-induced shrinkage of tail pieces. Histological study of the segments after 4 days of culture revealed that dbcAMP suppressed degenerative changes induced by T4. The inhibitory effect of prolactin on T4-induced tail regression was promoted by caffeine an inhibitor of adenosine 3',5'-cyclic monophosphate (cyclic AMP)-phosphodiesterase. The effect of prolactin on the level of cyclic AMP in the tail was also studied in vivo. Sixty min after prolactin injection, the cyclic AMP level was 2-3 times the control value. Possible involvement of cyclic AMP in the action of prolactin, which blocks tail resorption induced by T4, was discussed.

    Original languageEnglish
    Pages (from-to)255-261
    Number of pages7
    JournalDevelopment Growth and Differentiation
    Volume21
    Issue number3
    Publication statusPublished - 1979

    Fingerprint

    Thyroxine
    Prolactin
    Cyclic AMP
    Larva
    Tail
    Bucladesine
    Bufo bufo
    Phosphoric Diester Hydrolases
    Caffeine
    Injections

    ASJC Scopus subject areas

    • Cell Biology
    • Developmental Biology
    • Anatomy

    Cite this

    Inhibition of thyroxine-induced resorption of tadpole tail by adenosine 3',5'-cyclic monophosphate. / Yamamoto, K.; Kikuyama, S.; Yasumasu, I.

    In: Development Growth and Differentiation, Vol. 21, No. 3, 1979, p. 255-261.

    Research output: Contribution to journalArticle

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