Inhibitory action of 5-HT1A agonist MKC-242 on triazolam-induced phase advances in hamster circadian activity rhythms

Shin Ichi Yokota, Takahiro Moriya, Shigenobu Shibata

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Mammalian circadian rhythms can be entrained by photic and non-photic stimuli. Although we know that non-photic entrainment interferes with photic entrainment signals, there is no information about whether photic entrainment interferes with non-photic entraining signals. We examined whether triazolam (TRZ), a non-photic form of entrainment, could be attenuated by pre-treatment with (S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole hydrochloride (MKC-242), a photic enhancing drug. We found that TRZ-induced phase advances in hamster behavioral circadian rhythms and the increase of locomotor activity were both significantly attenuated by MKC-242. Thus, in hamsters, the photic enhancing drug MKC-242 seemed to hinder benzodiazepine-induced non-photic entrainment.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalJournal of Pharmacological Sciences
Volume98
Issue number1
DOIs
Publication statusPublished - 2005 May 1

Keywords

  • Benzodiazepine
  • Circadian rhythm
  • Non-photic

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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