Inhibitory action of 5-HT1A agonist MKC-242 on triazolam-induced phase advances in hamster circadian activity rhythms

Shin Ichi Yokota, Takahiro Moriya, Shigenobu Shibata

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Mammalian circadian rhythms can be entrained by photic and non-photic stimuli. Although we know that non-photic entrainment interferes with photic entrainment signals, there is no information about whether photic entrainment interferes with non-photic entraining signals. We examined whether triazolam (TRZ), a non-photic form of entrainment, could be attenuated by pre-treatment with (S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole hydrochloride (MKC-242), a photic enhancing drug. We found that TRZ-induced phase advances in hamster behavioral circadian rhythms and the increase of locomotor activity were both significantly attenuated by MKC-242. Thus, in hamsters, the photic enhancing drug MKC-242 seemed to hinder benzodiazepine-induced non-photic entrainment.

    Original languageEnglish
    Pages (from-to)103-106
    Number of pages4
    JournalJournal of Pharmacological Sciences
    Volume98
    Issue number1
    DOIs
    Publication statusPublished - 2005 May

    Fingerprint

    Triazolam
    Serotonin 5-HT1 Receptor Agonists
    Circadian Rhythm
    Cricetinae
    Locomotion
    Benzodiazepines
    Pharmaceutical Preparations
    osemozotan

    Keywords

    • Benzodiazepine
    • Circadian rhythm
    • Non-photic

    ASJC Scopus subject areas

    • Pharmacology

    Cite this

    Inhibitory action of 5-HT1A agonist MKC-242 on triazolam-induced phase advances in hamster circadian activity rhythms. / Yokota, Shin Ichi; Moriya, Takahiro; Shibata, Shigenobu.

    In: Journal of Pharmacological Sciences, Vol. 98, No. 1, 05.2005, p. 103-106.

    Research output: Contribution to journalArticle

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