Inhibitory action of insulin on suprachiasmatic nucleus neurons in rat hypothalamic slice preparations

Shigenobu Shibata, Shyh Yuh Liou, Showa Ueki, Yutaka Oomura

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

In order to elucidate a role of insulin on neurons in the suprachiasmatic nucleus (SCN) involved in the generation of circadian feeding behavior, we examined the effect of insulin on SCN neuronal activity at in vitro condition. Bath application of insulin (1-100 μU) mainly inhibited the SCN neuronal activity, and this inhibitory effect was still observed in a Ca2+-free Krebs solution. The present result strongly suggests that insulin directly inhibits SCN neurons and may explain an increase in food intake by insulin infusion into the SCN during the light period.

Original languageEnglish
Pages (from-to)79-81
Number of pages3
JournalPhysiology and Behavior
Volume36
Issue number1
DOIs
Publication statusPublished - 1986 Jan
Externally publishedYes

Keywords

  • Feeding rhythm
  • Insulin
  • Rat brain slice
  • Single unit activity
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Inhibitory action of insulin on suprachiasmatic nucleus neurons in rat hypothalamic slice preparations'. Together they form a unique fingerprint.

Cite this