Inhibitory action of insulin on suprachiasmatic nucleus neurons in rat hypothalamic slice preparations

Shigenobu Shibata; Shyh Yuh Liou; Showa Ueki; Yutaka Oomura

doi:10.1016/0031-9384(86)90077-6

Inhibitory action of insulin on suprachiasmatic nucleus neurons in rat hypothalamic slice preparations

Shigenobu Shibata^*, Shyh Yuh Liou, Showa Ueki, Yutaka Oomura

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

In order to elucidate a role of insulin on neurons in the suprachiasmatic nucleus (SCN) involved in the generation of circadian feeding behavior, we examined the effect of insulin on SCN neuronal activity at in vitro condition. Bath application of insulin (1-100 μU) mainly inhibited the SCN neuronal activity, and this inhibitory effect was still observed in a Ca²⁺-free Krebs solution. The present result strongly suggests that insulin directly inhibits SCN neurons and may explain an increase in food intake by insulin infusion into the SCN during the light period.

Original language	English
Pages (from-to)	79-81
Number of pages	3
Journal	Physiology and Behavior
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/0031-9384(86)90077-6
Publication status	Published - 1986 Jan
Externally published	Yes

Keywords

Feeding rhythm
Insulin
Rat brain slice
Single unit activity
Suprachiasmatic nucleus

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(86)90077-6

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title = "Inhibitory action of insulin on suprachiasmatic nucleus neurons in rat hypothalamic slice preparations",

abstract = "In order to elucidate a role of insulin on neurons in the suprachiasmatic nucleus (SCN) involved in the generation of circadian feeding behavior, we examined the effect of insulin on SCN neuronal activity at in vitro condition. Bath application of insulin (1-100 μU) mainly inhibited the SCN neuronal activity, and this inhibitory effect was still observed in a Ca2+-free Krebs solution. The present result strongly suggests that insulin directly inhibits SCN neurons and may explain an increase in food intake by insulin infusion into the SCN during the light period.",

keywords = "Feeding rhythm, Insulin, Rat brain slice, Single unit activity, Suprachiasmatic nucleus",

author = "Shigenobu Shibata and Liou, {Shyh Yuh} and Showa Ueki and Yutaka Oomura",

year = "1986",

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T1 - Inhibitory action of insulin on suprachiasmatic nucleus neurons in rat hypothalamic slice preparations

AU - Shibata, Shigenobu

AU - Liou, Shyh Yuh

AU - Ueki, Showa

AU - Oomura, Yutaka

PY - 1986/1

Y1 - 1986/1

N2 - In order to elucidate a role of insulin on neurons in the suprachiasmatic nucleus (SCN) involved in the generation of circadian feeding behavior, we examined the effect of insulin on SCN neuronal activity at in vitro condition. Bath application of insulin (1-100 μU) mainly inhibited the SCN neuronal activity, and this inhibitory effect was still observed in a Ca2+-free Krebs solution. The present result strongly suggests that insulin directly inhibits SCN neurons and may explain an increase in food intake by insulin infusion into the SCN during the light period.

AB - In order to elucidate a role of insulin on neurons in the suprachiasmatic nucleus (SCN) involved in the generation of circadian feeding behavior, we examined the effect of insulin on SCN neuronal activity at in vitro condition. Bath application of insulin (1-100 μU) mainly inhibited the SCN neuronal activity, and this inhibitory effect was still observed in a Ca2+-free Krebs solution. The present result strongly suggests that insulin directly inhibits SCN neurons and may explain an increase in food intake by insulin infusion into the SCN during the light period.

KW - Feeding rhythm

KW - Insulin

KW - Rat brain slice

KW - Single unit activity

KW - Suprachiasmatic nucleus

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SN - 0031-9384

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EP - 81

JO - Physiology and Behavior

JF - Physiology and Behavior

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Inhibitory action of insulin on suprachiasmatic nucleus neurons in rat hypothalamic slice preparations

Abstract

Keywords

ASJC Scopus subject areas

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