Inhibitory and excitatory effects of histamine on suprachiasmatic neurons in rat hypothalamic slice preparation

Shyh Yuh Liou, Shigenobu Shibata, Katsunori Yamakawa, Showa Ueki

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The effects of histamine (HA) and serotonin (5-HT) on single neurons of the suprachiasmatic nucleus (SCN) in hypothalamic slices were investigated by iontophoretic application. Sixty-two of 181 cells were inhibited by HA, whereas 30 were excited. Forty-nine of 163 cells were inhibited by 5-HT, whereas 9 were excited. Pyrilamine, an H1-antagonist, slightly (2/7), and cimetidine, an H2-antagonist, strongly (10/13) antagonized the inhibitory effect of HA. The excitatory effect of HA was not antagonized by cimetidine (0/4), but was perfectly antagonized by pyrilamine (5/5). The present results suggest that HA and 5-HT play mainly an inhibitory role in the SCN neuronal activity, and that inhibition and excitation induced by HA may be mediated by H2- and H1-receptors, respectively.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalNeuroscience Letters
Volume41
Issue number1-2
DOIs
Publication statusPublished - 1983 Oct 31
Externally publishedYes

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Histamine
Neurons
Serotonin
Pyrilamine
Suprachiasmatic Nucleus
Cimetidine
Histamine H1 Receptors
Histamine H2 Receptors

Keywords

  • histamine
  • rat hypothalamic slice
  • serotonin
  • single units
  • suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Inhibitory and excitatory effects of histamine on suprachiasmatic neurons in rat hypothalamic slice preparation. / Yuh Liou, Shyh; Shibata, Shigenobu; Yamakawa, Katsunori; Ueki, Showa.

In: Neuroscience Letters, Vol. 41, No. 1-2, 31.10.1983, p. 109-113.

Research output: Contribution to journalArticle

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AU - Ueki, Showa

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N2 - The effects of histamine (HA) and serotonin (5-HT) on single neurons of the suprachiasmatic nucleus (SCN) in hypothalamic slices were investigated by iontophoretic application. Sixty-two of 181 cells were inhibited by HA, whereas 30 were excited. Forty-nine of 163 cells were inhibited by 5-HT, whereas 9 were excited. Pyrilamine, an H1-antagonist, slightly (2/7), and cimetidine, an H2-antagonist, strongly (10/13) antagonized the inhibitory effect of HA. The excitatory effect of HA was not antagonized by cimetidine (0/4), but was perfectly antagonized by pyrilamine (5/5). The present results suggest that HA and 5-HT play mainly an inhibitory role in the SCN neuronal activity, and that inhibition and excitation induced by HA may be mediated by H2- and H1-receptors, respectively.

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