Inhibitory control of shivering and nonshivering thermogenesis by preoptic warm-sensitive neurons

Kazuyuki Kanosue, X. M. Chen, T. Hosono, T. Yoda, S. Liu

Research output: Contribution to journalArticle

Abstract

To investigate the characteristics of efferent projections from the preoptic area for the control of shivering and nonshivering thermogenesis, we tested the effects of thermal stimulation and injecting excitatory substances into the preoptic area on shivering and nonshivering thermogenesis in anesthetized rats. Preoptic warming and injection of glutamate suppressed shivering at ambient temperatures of 15-21°C. Likewise, preoptic warming and D,L-homocysteic acid injection suppressed nonshivering thermogenesis elicited by electrical stimulation of the ventromedial hypothalamic nucleus. Inhibitory signals from warm-sensitive neurons, thus, contribute a larger efferent signal for heat production than do signals from cold-sensitive neurons.

Original languageEnglish
Pages (from-to)351-354
Number of pages4
JournalJournal of Thermal Biology
Volume24
Issue number5-6
DOIs
Publication statusPublished - 1999 Oct
Externally publishedYes

Fingerprint

Shivering
Thermogenesis
heat production
Neurons
neurons
preoptic area
Preoptic Area
Rats
Glutamic Acid
Ventromedial Hypothalamic Nucleus
injection
Injections
glutamates
Electric Stimulation
ambient temperature
Hot Temperature
heat
Temperature
acids
rats

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physiology

Cite this

Inhibitory control of shivering and nonshivering thermogenesis by preoptic warm-sensitive neurons. / Kanosue, Kazuyuki; Chen, X. M.; Hosono, T.; Yoda, T.; Liu, S.

In: Journal of Thermal Biology, Vol. 24, No. 5-6, 10.1999, p. 351-354.

Research output: Contribution to journalArticle

Kanosue, Kazuyuki ; Chen, X. M. ; Hosono, T. ; Yoda, T. ; Liu, S. / Inhibitory control of shivering and nonshivering thermogenesis by preoptic warm-sensitive neurons. In: Journal of Thermal Biology. 1999 ; Vol. 24, No. 5-6. pp. 351-354.
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