Inhibitory control of shivering and nonshivering thermogenesis by preoptic warm-sensitive neurons

K. Kanosue; X. M. Chen; T. Hosono; T. Yoda; S. Liu

doi:10.1016/S0306-4565(99)00061-3

Inhibitory control of shivering and nonshivering thermogenesis by preoptic warm-sensitive neurons

K. Kanosue^*, X. M. Chen, T. Hosono, T. Yoda, S. Liu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

To investigate the characteristics of efferent projections from the preoptic area for the control of shivering and nonshivering thermogenesis, we tested the effects of thermal stimulation and injecting excitatory substances into the preoptic area on shivering and nonshivering thermogenesis in anesthetized rats. Preoptic warming and injection of glutamate suppressed shivering at ambient temperatures of 15-21°C. Likewise, preoptic warming and D,L-homocysteic acid injection suppressed nonshivering thermogenesis elicited by electrical stimulation of the ventromedial hypothalamic nucleus. Inhibitory signals from warm-sensitive neurons, thus, contribute a larger efferent signal for heat production than do signals from cold-sensitive neurons.

Original language	English
Pages (from-to)	351-354
Number of pages	4
Journal	Journal of Thermal Biology
Volume	24
Issue number	5-6
DOIs	https://doi.org/10.1016/S0306-4565(99)00061-3
Publication status	Published - 1999 Oct
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physiology
Agricultural and Biological Sciences(all)
Developmental Biology

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10.1016/S0306-4565(99)00061-3

Cite this

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title = "Inhibitory control of shivering and nonshivering thermogenesis by preoptic warm-sensitive neurons",

abstract = "To investigate the characteristics of efferent projections from the preoptic area for the control of shivering and nonshivering thermogenesis, we tested the effects of thermal stimulation and injecting excitatory substances into the preoptic area on shivering and nonshivering thermogenesis in anesthetized rats. Preoptic warming and injection of glutamate suppressed shivering at ambient temperatures of 15-21°C. Likewise, preoptic warming and D,L-homocysteic acid injection suppressed nonshivering thermogenesis elicited by electrical stimulation of the ventromedial hypothalamic nucleus. Inhibitory signals from warm-sensitive neurons, thus, contribute a larger efferent signal for heat production than do signals from cold-sensitive neurons.",

author = "K. Kanosue and Chen, {X. M.} and T. Hosono and T. Yoda and S. Liu",

note = "Funding Information: This study is supported in part by a Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (Grants No. 9470016 and No. 04454143).",

year = "1999",

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doi = "10.1016/S0306-4565(99)00061-3",

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AU - Kanosue, K.

AU - Chen, X. M.

AU - Hosono, T.

AU - Yoda, T.

AU - Liu, S.

N1 - Funding Information: This study is supported in part by a Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (Grants No. 9470016 and No. 04454143).

PY - 1999/10

Y1 - 1999/10

N2 - To investigate the characteristics of efferent projections from the preoptic area for the control of shivering and nonshivering thermogenesis, we tested the effects of thermal stimulation and injecting excitatory substances into the preoptic area on shivering and nonshivering thermogenesis in anesthetized rats. Preoptic warming and injection of glutamate suppressed shivering at ambient temperatures of 15-21°C. Likewise, preoptic warming and D,L-homocysteic acid injection suppressed nonshivering thermogenesis elicited by electrical stimulation of the ventromedial hypothalamic nucleus. Inhibitory signals from warm-sensitive neurons, thus, contribute a larger efferent signal for heat production than do signals from cold-sensitive neurons.

AB - To investigate the characteristics of efferent projections from the preoptic area for the control of shivering and nonshivering thermogenesis, we tested the effects of thermal stimulation and injecting excitatory substances into the preoptic area on shivering and nonshivering thermogenesis in anesthetized rats. Preoptic warming and injection of glutamate suppressed shivering at ambient temperatures of 15-21°C. Likewise, preoptic warming and D,L-homocysteic acid injection suppressed nonshivering thermogenesis elicited by electrical stimulation of the ventromedial hypothalamic nucleus. Inhibitory signals from warm-sensitive neurons, thus, contribute a larger efferent signal for heat production than do signals from cold-sensitive neurons.

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Inhibitory control of shivering and nonshivering thermogenesis by preoptic warm-sensitive neurons

Abstract

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