Inhibitory effect of crude-drug extracts on the degranulation of mast cells (RBL-2H3)

Mariko Asano, Megumi Dohi, Kazunaga Yazawa, Takashi Kometani, Kyoko Takahashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The prevalence of type I allergies, including food allergies and atopic dermatitis is increasing worldwide. Chinese medicines and crude drugs have been used for treatment of these allergies ; however, the mechanisms of the treatment efects remain unclear. In the present study, we investigated the inhibitory efects of crude drugs on the degranulation of mast cells using the crude hot-water extracts of 83 types of crude drugs. Among the crude drugs, extracts from Ni-kei, fun-bo-i, ku-se-ki and on-ji most significantly inhibited the release of b-hexosaminidase in RBL-2H3 cells, with IC50 values of 215.7, 79.1, 187.6 and 288.1 ug/ml, respectively.

Original languageEnglish
Pages (from-to)330-334
Number of pages5
JournalNippon Shokuhin Kagaku Kogaku Kaishi
Volume58
Issue number7
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

mast cells
Complex Mixtures
Mast Cells
drugs
extracts
hypersensitivity
Pharmaceutical Preparations
Hypersensitivity
beta-N-acetylhexosaminidase
Hexosaminidases
food allergies
atopic dermatitis
Food Hypersensitivity
Atopic Dermatitis
Inhibitory Concentration 50
inhibitory concentration 50
medicine
Water
water
cells

Keywords

  • Crude drug
  • Degranulation
  • Typel allergy

ASJC Scopus subject areas

  • Food Science

Cite this

Inhibitory effect of crude-drug extracts on the degranulation of mast cells (RBL-2H3). / Asano, Mariko; Dohi, Megumi; Yazawa, Kazunaga; Kometani, Takashi; Takahashi, Kyoko.

In: Nippon Shokuhin Kagaku Kogaku Kaishi, Vol. 58, No. 7, 2011, p. 330-334.

Research output: Contribution to journalArticle

Asano, Mariko ; Dohi, Megumi ; Yazawa, Kazunaga ; Kometani, Takashi ; Takahashi, Kyoko. / Inhibitory effect of crude-drug extracts on the degranulation of mast cells (RBL-2H3). In: Nippon Shokuhin Kagaku Kogaku Kaishi. 2011 ; Vol. 58, No. 7. pp. 330-334.
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