Inhibitory effect of neural transections of dorsal raphe nucleus on induction of nocturnal prolactin surge by vaginal stimulation in ovariectomized rats

Fumihiko Maekawa, Shinji Tsukahara, Hiroko Tsukamura, Kei Ichiro Maeda, Korehito Yamanouchi

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    The effect of complete (CC), anterior (AC) or posterior (PC) cut of the dorsal raphe nucleus (DRn) on induction of the nocturnal prolactin (PRL) surge by electrical vaginal stimulation (VS) was investigated in ovariectomized rats. Plasma level of PRL was measured by radioimmunoassay before and after VS. The data revealed that PRL levels increased in early morning on the day following VS in the rats without brain surgery or with sham-operation. In contrast, the nocturnal PRL surge did not occur in the CC, AC, or PC rats. These results suggest that both the anterior and the posterior fibers of the DRn plays an important role in induction of nocturnal PRL surge by VS in ovariectomized rats.

    Original languageEnglish
    Pages (from-to)195-199
    Number of pages5
    JournalBrain Research
    Volume813
    Issue number1
    DOIs
    Publication statusPublished - 1998 Nov 30

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    Prolactin
    Electric Stimulation
    Radioimmunoassay
    Dorsal Raphe Nucleus
    Brain

    Keywords

    • Dorsal raphe nucleus
    • Neural transection
    • Prolactin
    • Pseudopregnancy
    • Radioimmunoassay
    • Rat

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Inhibitory effect of neural transections of dorsal raphe nucleus on induction of nocturnal prolactin surge by vaginal stimulation in ovariectomized rats. / Maekawa, Fumihiko; Tsukahara, Shinji; Tsukamura, Hiroko; Maeda, Kei Ichiro; Yamanouchi, Korehito.

    In: Brain Research, Vol. 813, No. 1, 30.11.1998, p. 195-199.

    Research output: Contribution to journalArticle

    Maekawa, Fumihiko ; Tsukahara, Shinji ; Tsukamura, Hiroko ; Maeda, Kei Ichiro ; Yamanouchi, Korehito. / Inhibitory effect of neural transections of dorsal raphe nucleus on induction of nocturnal prolactin surge by vaginal stimulation in ovariectomized rats. In: Brain Research. 1998 ; Vol. 813, No. 1. pp. 195-199.
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    abstract = "The effect of complete (CC), anterior (AC) or posterior (PC) cut of the dorsal raphe nucleus (DRn) on induction of the nocturnal prolactin (PRL) surge by electrical vaginal stimulation (VS) was investigated in ovariectomized rats. Plasma level of PRL was measured by radioimmunoassay before and after VS. The data revealed that PRL levels increased in early morning on the day following VS in the rats without brain surgery or with sham-operation. In contrast, the nocturnal PRL surge did not occur in the CC, AC, or PC rats. These results suggest that both the anterior and the posterior fibers of the DRn plays an important role in induction of nocturnal PRL surge by VS in ovariectomized rats.",
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