Inhibitory effect of neural transections of dorsal raphe nucleus on induction of nocturnal prolactin surge by vaginal stimulation in ovariectomized rats

Fumihiko Maekawa; Shinji Tsukahara; Hiroko Tsukamura; Kei Ichiro Maeda; Korehito Yamanouchi

doi:10.1016/S0006-8993(98)01019-1

Inhibitory effect of neural transections of dorsal raphe nucleus on induction of nocturnal prolactin surge by vaginal stimulation in ovariectomized rats

Fumihiko Maekawa, Shinji Tsukahara, Hiroko Tsukamura, Kei Ichiro Maeda, Korehito Yamanouchi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The effect of complete (CC), anterior (AC) or posterior (PC) cut of the dorsal raphe nucleus (DRn) on induction of the nocturnal prolactin (PRL) surge by electrical vaginal stimulation (VS) was investigated in ovariectomized rats. Plasma level of PRL was measured by radioimmunoassay before and after VS. The data revealed that PRL levels increased in early morning on the day following VS in the rats without brain surgery or with sham-operation. In contrast, the nocturnal PRL surge did not occur in the CC, AC, or PC rats. These results suggest that both the anterior and the posterior fibers of the DRn plays an important role in induction of nocturnal PRL surge by VS in ovariectomized rats.

Original language	English
Pages (from-to)	195-199
Number of pages	5
Journal	Brain Research
Volume	813
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(98)01019-1
Publication status	Published - 1998 Nov 30

Keywords

Dorsal raphe nucleus
Neural transection
Prolactin
Pseudopregnancy
Radioimmunoassay
Rat

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/S0006-8993(98)01019-1

Cite this

@article{4bb0b26a43364f3b8d5218adc0b68819,

title = "Inhibitory effect of neural transections of dorsal raphe nucleus on induction of nocturnal prolactin surge by vaginal stimulation in ovariectomized rats",

abstract = "The effect of complete (CC), anterior (AC) or posterior (PC) cut of the dorsal raphe nucleus (DRn) on induction of the nocturnal prolactin (PRL) surge by electrical vaginal stimulation (VS) was investigated in ovariectomized rats. Plasma level of PRL was measured by radioimmunoassay before and after VS. The data revealed that PRL levels increased in early morning on the day following VS in the rats without brain surgery or with sham-operation. In contrast, the nocturnal PRL surge did not occur in the CC, AC, or PC rats. These results suggest that both the anterior and the posterior fibers of the DRn plays an important role in induction of nocturnal PRL surge by VS in ovariectomized rats.",

keywords = "Dorsal raphe nucleus, Neural transection, Prolactin, Pseudopregnancy, Radioimmunoassay, Rat",

author = "Fumihiko Maekawa and Shinji Tsukahara and Hiroko Tsukamura and Maeda, {Kei Ichiro} and Korehito Yamanouchi",

year = "1998",

month = nov,

day = "30",

doi = "10.1016/S0006-8993(98)01019-1",

language = "English",

volume = "813",

pages = "195--199",

journal = "Brain Research Protocols",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Inhibitory effect of neural transections of dorsal raphe nucleus on induction of nocturnal prolactin surge by vaginal stimulation in ovariectomized rats

AU - Maekawa, Fumihiko

AU - Tsukahara, Shinji

AU - Tsukamura, Hiroko

AU - Maeda, Kei Ichiro

AU - Yamanouchi, Korehito

PY - 1998/11/30

Y1 - 1998/11/30

N2 - The effect of complete (CC), anterior (AC) or posterior (PC) cut of the dorsal raphe nucleus (DRn) on induction of the nocturnal prolactin (PRL) surge by electrical vaginal stimulation (VS) was investigated in ovariectomized rats. Plasma level of PRL was measured by radioimmunoassay before and after VS. The data revealed that PRL levels increased in early morning on the day following VS in the rats without brain surgery or with sham-operation. In contrast, the nocturnal PRL surge did not occur in the CC, AC, or PC rats. These results suggest that both the anterior and the posterior fibers of the DRn plays an important role in induction of nocturnal PRL surge by VS in ovariectomized rats.

AB - The effect of complete (CC), anterior (AC) or posterior (PC) cut of the dorsal raphe nucleus (DRn) on induction of the nocturnal prolactin (PRL) surge by electrical vaginal stimulation (VS) was investigated in ovariectomized rats. Plasma level of PRL was measured by radioimmunoassay before and after VS. The data revealed that PRL levels increased in early morning on the day following VS in the rats without brain surgery or with sham-operation. In contrast, the nocturnal PRL surge did not occur in the CC, AC, or PC rats. These results suggest that both the anterior and the posterior fibers of the DRn plays an important role in induction of nocturnal PRL surge by VS in ovariectomized rats.

KW - Dorsal raphe nucleus

KW - Neural transection

KW - Prolactin

KW - Pseudopregnancy

KW - Radioimmunoassay

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=0032583267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032583267&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(98)01019-1

DO - 10.1016/S0006-8993(98)01019-1

M3 - Article

C2 - 9824697

AN - SCOPUS:0032583267

SN - 0006-8993

VL - 813

SP - 195

EP - 199

JO - Brain Research Protocols

JF - Brain Research Protocols

IS - 1

ER -

Inhibitory effect of neural transections of dorsal raphe nucleus on induction of nocturnal prolactin surge by vaginal stimulation in ovariectomized rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this