Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung

M. Iigo, T. Nakagawa, C. Ishikawa, Y. Iwahori, M. Asamoto, Kazunaga Yazawa, E. Araki, H. Tsuda

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Unsaturated fatty acids, including n-3 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (C(22:6), DHA) and eicosapentaenoic acid (C(20:5), EPA), and a series of n-6 PUFAs were investigated for their anti-tumour and antimetastatic effects in a subcutaneous (s.c.) implanted highly metastatic colon carcinoma 26 (Co 26Lu) model. EPA and DHA exerted significant inhibitory effects on tumour growth at the implantation site and significantly decreased the numbers of lung metastatic nodules. Oleic acid also significantly inhibited lung metastatic nodules. Treatment with arachidonic acid showed a tendency for reduction in colonization. However, treatment with high doses of fatty acids, especially linoleic acid, increased the numbers of lung metastatic nodules. DHA and EPA only inhibited lung colonizations when administered together with the tumour cells, suggesting that their incorporation is necessary for an influence to be exerted. Chromatography confirmed that contents of fatty acids in both tumour tissues and plasma were indeed affected by the treatments. Tumour cells pretreated with fatty acids in vivo, in particular DHA, also showed a low potential for lung colony formation when transferred to new hosts. Thus, DHA treatment exerted marked antimetastatic activity associated with pronounced change in the fatty acid component of tumour cells. The results indicate that uptake of DHA into tumour cells results in altered tumour cell membrane characteristics and a decreased ability to metastasize.

Original languageEnglish
Pages (from-to)650-655
Number of pages6
JournalBritish Journal of Cancer
Volume75
Issue number5
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Docosahexaenoic Acids
Colon
Neoplasm Metastasis
Carcinoma
Lung
Neoplasms
Fatty Acids
Unsaturated Fatty Acids
Eicosapentaenoic Acid
Omega-3 Fatty Acids
Linoleic Acid
Cellular Structures
Oleic Acid
Arachidonic Acid
Chromatography
Cell Membrane
Growth

Keywords

  • Colon carcinoma 26
  • Docosahexaenoic acid
  • Metastasis
  • Unsaturated fatty acid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Iigo, M., Nakagawa, T., Ishikawa, C., Iwahori, Y., Asamoto, M., Yazawa, K., ... Tsuda, H. (1997). Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. British Journal of Cancer, 75(5), 650-655.

Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. / Iigo, M.; Nakagawa, T.; Ishikawa, C.; Iwahori, Y.; Asamoto, M.; Yazawa, Kazunaga; Araki, E.; Tsuda, H.

In: British Journal of Cancer, Vol. 75, No. 5, 1997, p. 650-655.

Research output: Contribution to journalArticle

Iigo, M, Nakagawa, T, Ishikawa, C, Iwahori, Y, Asamoto, M, Yazawa, K, Araki, E & Tsuda, H 1997, 'Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung', British Journal of Cancer, vol. 75, no. 5, pp. 650-655.
Iigo M, Nakagawa T, Ishikawa C, Iwahori Y, Asamoto M, Yazawa K et al. Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. British Journal of Cancer. 1997;75(5):650-655.
Iigo, M. ; Nakagawa, T. ; Ishikawa, C. ; Iwahori, Y. ; Asamoto, M. ; Yazawa, Kazunaga ; Araki, E. ; Tsuda, H. / Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. In: British Journal of Cancer. 1997 ; Vol. 75, No. 5. pp. 650-655.
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