Abstract
Flexible materials are important for the development of neural probes in recording stable signals (spikes) in vivo. Here, we present inkjet-printed, flexible neural probes for spike recording by using polymeric thin films. The neural probes were constructed from 400 nm-thick poly(d,l-lactic acid) nanofilms, inkjet-printed lines consisting of Au and poly(3,4-ethylenedioxythiophene):polystyrenesulfonate nanoinks, and fluoropolymer layers. Microelectrodes were exposed by cutting the edge with a razor. The 6 μm-thick probes were connected to the external amplifiers by gradual increase of stiffness with thickness-dependent manner. The probe was formed into a needle shape, which recorded spikes from mouse thalamus in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 20-26 |
| Number of pages | 7 |
| Journal | ACS Applied Bio Materials |
| Volume | 2 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2019 Jan 22 |
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Keywords
- inkjet printing
- neural electrode
- optogenetics
- polymer nanofilm
- printed electronics
ASJC Scopus subject areas
- Biomaterials
- Chemistry(all)
- Biomedical Engineering
- Biochemistry, medical
Cite this
Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure. / Kokubo, Nana; Arake, Masashi; Yamagishi, Kento; Morimoto, Yuji; Takeoka, Shinji; Ohta, Hiroyuki; Fujie, Toshinori.
In: ACS Applied Bio Materials, Vol. 2, No. 1, 22.01.2019, p. 20-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure
AU - Kokubo, Nana
AU - Arake, Masashi
AU - Yamagishi, Kento
AU - Morimoto, Yuji
AU - Takeoka, Shinji
AU - Ohta, Hiroyuki
AU - Fujie, Toshinori
PY - 2019/1/22
Y1 - 2019/1/22
N2 - Flexible materials are important for the development of neural probes in recording stable signals (spikes) in vivo. Here, we present inkjet-printed, flexible neural probes for spike recording by using polymeric thin films. The neural probes were constructed from 400 nm-thick poly(d,l-lactic acid) nanofilms, inkjet-printed lines consisting of Au and poly(3,4-ethylenedioxythiophene):polystyrenesulfonate nanoinks, and fluoropolymer layers. Microelectrodes were exposed by cutting the edge with a razor. The 6 μm-thick probes were connected to the external amplifiers by gradual increase of stiffness with thickness-dependent manner. The probe was formed into a needle shape, which recorded spikes from mouse thalamus in vivo.
AB - Flexible materials are important for the development of neural probes in recording stable signals (spikes) in vivo. Here, we present inkjet-printed, flexible neural probes for spike recording by using polymeric thin films. The neural probes were constructed from 400 nm-thick poly(d,l-lactic acid) nanofilms, inkjet-printed lines consisting of Au and poly(3,4-ethylenedioxythiophene):polystyrenesulfonate nanoinks, and fluoropolymer layers. Microelectrodes were exposed by cutting the edge with a razor. The 6 μm-thick probes were connected to the external amplifiers by gradual increase of stiffness with thickness-dependent manner. The probe was formed into a needle shape, which recorded spikes from mouse thalamus in vivo.
KW - inkjet printing
KW - neural electrode
KW - optogenetics
KW - polymer nanofilm
KW - printed electronics
UR - http://www.scopus.com/inward/record.url?scp=85072766419&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072766419&partnerID=8YFLogxK
U2 - 10.1021/acsabm.8b00574
DO - 10.1021/acsabm.8b00574
M3 - Article
AN - SCOPUS:85072766419
VL - 2
SP - 20
EP - 26
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
SN - 2576-6422
IS - 1
ER -