Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure

Nana Kokubo; Masashi Arake; Kento Yamagishi; Yuji Morimoto; Shinji Takeoka; Hiroyuki Ohta; Toshinori Fujie

doi:10.1021/acsabm.8b00574

Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure

Nana Kokubo, Masashi Arake, Kento Yamagishi, Yuji Morimoto, Shinji Takeoka, Hiroyuki Ohta, Toshinori Fujie

School of Advanced Science and Engineering

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Flexible materials are important for the development of neural probes in recording stable signals (spikes) in vivo. Here, we present inkjet-printed, flexible neural probes for spike recording by using polymeric thin films. The neural probes were constructed from 400 nm-thick poly(d,l-lactic acid) nanofilms, inkjet-printed lines consisting of Au and poly(3,4-ethylenedioxythiophene):polystyrenesulfonate nanoinks, and fluoropolymer layers. Microelectrodes were exposed by cutting the edge with a razor. The 6 μm-thick probes were connected to the external amplifiers by gradual increase of stiffness with thickness-dependent manner. The probe was formed into a needle shape, which recorded spikes from mouse thalamus in vivo.

Original language	English
Pages (from-to)	20-26
Number of pages	7
Journal	ACS Applied Bio Materials
Volume	2
Issue number	1
DOIs	https://doi.org/10.1021/acsabm.8b00574
Publication status	Published - 2019 Jan 22

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Keywords

inkjet printing
neural electrode
optogenetics
polymer nanofilm
printed electronics

ASJC Scopus subject areas

Biomaterials
Chemistry(all)
Biomedical Engineering
Biochemistry, medical

Cite this

Kokubo, N., Arake, M., Yamagishi, K., Morimoto, Y., Takeoka, S., Ohta, H., & Fujie, T. (2019). Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure. ACS Applied Bio Materials, 2(1), 20-26. https://doi.org/10.1021/acsabm.8b00574

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Access to Document

10.1021/acsabm.8b00574