Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure

Nana Kokubo, Masashi Arake, Kento Yamagishi, Yuji Morimoto, Shinji Takeoka, Hiroyuki Ohta*, Toshinori Fujie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Flexible materials are important for the development of neural probes in recording stable signals (spikes) in vivo. Here, we present inkjet-printed, flexible neural probes for spike recording by using polymeric thin films. The neural probes were constructed from 400 nm-thick poly(d,l-lactic acid) nanofilms, inkjet-printed lines consisting of Au and poly(3,4-ethylenedioxythiophene):polystyrenesulfonate nanoinks, and fluoropolymer layers. Microelectrodes were exposed by cutting the edge with a razor. The 6 μm-thick probes were connected to the external amplifiers by gradual increase of stiffness with thickness-dependent manner. The probe was formed into a needle shape, which recorded spikes from mouse thalamus in vivo.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalACS Applied Bio Materials
Issue number1
Publication statusPublished - 2019 Jan 22


  • inkjet printing
  • neural electrode
  • optogenetics
  • polymer nanofilm
  • printed electronics

ASJC Scopus subject areas

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical


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