Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure

Nana Kokubo, Masashi Arake, Kento Yamagishi, Yuji Morimoto, Shinji Takeoka, Hiroyuki Ohta, Toshinori Fujie

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Flexible materials are important for the development of neural probes in recording stable signals (spikes) in vivo. Here, we present inkjet-printed, flexible neural probes for spike recording by using polymeric thin films. The neural probes were constructed from 400 nm-thick poly(d,l-lactic acid) nanofilms, inkjet-printed lines consisting of Au and poly(3,4-ethylenedioxythiophene):polystyrenesulfonate nanoinks, and fluoropolymer layers. Microelectrodes were exposed by cutting the edge with a razor. The 6 μm-thick probes were connected to the external amplifiers by gradual increase of stiffness with thickness-dependent manner. The probe was formed into a needle shape, which recorded spikes from mouse thalamus in vivo.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalACS Applied Bio Materials
Volume2
Issue number1
DOIs
Publication statusPublished - 2019 Jan 22

Keywords

  • inkjet printing
  • neural electrode
  • optogenetics
  • polymer nanofilm
  • printed electronics

ASJC Scopus subject areas

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical

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  • Cite this

    Kokubo, N., Arake, M., Yamagishi, K., Morimoto, Y., Takeoka, S., Ohta, H., & Fujie, T. (2019). Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure. ACS Applied Bio Materials, 2(1), 20-26. https://doi.org/10.1021/acsabm.8b00574