Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure

Nana Kokubo, Masashi Arake, Kento Yamagishi, Yuji Morimoto, Shinji Takeoka, Hiroyuki Ohta, Toshinori Fujie

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Flexible materials are important for the development of neural probes in recording stable signals (spikes) in vivo. Here, we present inkjet-printed, flexible neural probes for spike recording by using polymeric thin films. The neural probes were constructed from 400 nm-thick poly(d,l-lactic acid) nanofilms, inkjet-printed lines consisting of Au and poly(3,4-ethylenedioxythiophene):polystyrenesulfonate nanoinks, and fluoropolymer layers. Microelectrodes were exposed by cutting the edge with a razor. The 6 μm-thick probes were connected to the external amplifiers by gradual increase of stiffness with thickness-dependent manner. The probe was formed into a needle shape, which recorded spikes from mouse thalamus in vivo.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalACS Applied Bio Materials
Volume2
Issue number1
DOIs
Publication statusPublished - 2019 Jan 22

Fingerprint

Microelectrodes
Thalamus
Needles
Electrodes
Fluorine containing polymers
Lactic acid
Polymer films
Stiffness
poly(lactic acid)
poly(3,4-ethylene dioxythiophene)
Thin films

Keywords

  • inkjet printing
  • neural electrode
  • optogenetics
  • polymer nanofilm
  • printed electronics

ASJC Scopus subject areas

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical

Cite this

Kokubo, N., Arake, M., Yamagishi, K., Morimoto, Y., Takeoka, S., Ohta, H., & Fujie, T. (2019). Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure. ACS Applied Bio Materials, 2(1), 20-26. https://doi.org/10.1021/acsabm.8b00574

Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure. / Kokubo, Nana; Arake, Masashi; Yamagishi, Kento; Morimoto, Yuji; Takeoka, Shinji; Ohta, Hiroyuki; Fujie, Toshinori.

In: ACS Applied Bio Materials, Vol. 2, No. 1, 22.01.2019, p. 20-26.

Research output: Contribution to journalArticle

Kokubo, N, Arake, M, Yamagishi, K, Morimoto, Y, Takeoka, S, Ohta, H & Fujie, T 2019, 'Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure', ACS Applied Bio Materials, vol. 2, no. 1, pp. 20-26. https://doi.org/10.1021/acsabm.8b00574
Kokubo, Nana ; Arake, Masashi ; Yamagishi, Kento ; Morimoto, Yuji ; Takeoka, Shinji ; Ohta, Hiroyuki ; Fujie, Toshinori. / Inkjet-Printed Neural Electrodes with Mechanically Gradient Structure. In: ACS Applied Bio Materials. 2019 ; Vol. 2, No. 1. pp. 20-26.
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