Abstract
Although there are many reports of the high diagnostic accuracy of commercially available serologic kits for Helicobacter pylori infection in Western countries, they rarely has been investigated in oriental population. Accordingly we examined their usefulness in 492 Japanese patients with dyspeptic symptoms. Diagnostic accuracy of 4 imported serologic kits (HEL-p TEST(TM), HM CAP(TM), G.A.P IgG(TM), Helico G2(TM)) was investigated using the 13C-urea breath test as the gold standard. When intermediate results were excluded, the sensitivity, specificity and accuracy of these serologic tests ranged from 88.6% to 97.8%, 67.9% to 85.9%, and 87.9% to 91.4%, respectively, which were comparable with reported median accuracy in the Western population. However, there were many intermediate results in these tests, ranging from 5.3% to 23.0%. Their usefulness seemed to be limited in our patient population because of the large number of intermediate results. Copyright (C) 2000 Elsevier Science Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 95-99 |
| Number of pages | 5 |
| Journal | Diagnostic Microbiology and Infectious Disease |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2000 Feb |
| Externally published | Yes |
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Keywords
- Breath test
- ELISA
- GAP IgG
- HeL p
- Helico G2
- HM CAP
ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Allergy
- Virology
- Parasitology
- Microbiology
- Immunology
- Applied Microbiology and Biotechnology
Cite this
Insufficient diagnostic accuracy of imported serological kits for Helicobacter pylori infection in Japanese population. / Miwa, Hiroto; Kikuchi, Shogo; Ohtaka, Keiichi; Kobayashi, Osamu; Ogihara, Atsushi; Hojo, Mariko; Nagahara, Akihito; Sato, Nobuhiro.
In: Diagnostic Microbiology and Infectious Disease, Vol. 36, No. 2, 02.2000, p. 95-99.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insufficient diagnostic accuracy of imported serological kits for Helicobacter pylori infection in Japanese population
AU - Miwa, Hiroto
AU - Kikuchi, Shogo
AU - Ohtaka, Keiichi
AU - Kobayashi, Osamu
AU - Ogihara, Atsushi
AU - Hojo, Mariko
AU - Nagahara, Akihito
AU - Sato, Nobuhiro
PY - 2000/2
Y1 - 2000/2
N2 - Although there are many reports of the high diagnostic accuracy of commercially available serologic kits for Helicobacter pylori infection in Western countries, they rarely has been investigated in oriental population. Accordingly we examined their usefulness in 492 Japanese patients with dyspeptic symptoms. Diagnostic accuracy of 4 imported serologic kits (HEL-p TEST(TM), HM CAP(TM), G.A.P IgG(TM), Helico G2(TM)) was investigated using the 13C-urea breath test as the gold standard. When intermediate results were excluded, the sensitivity, specificity and accuracy of these serologic tests ranged from 88.6% to 97.8%, 67.9% to 85.9%, and 87.9% to 91.4%, respectively, which were comparable with reported median accuracy in the Western population. However, there were many intermediate results in these tests, ranging from 5.3% to 23.0%. Their usefulness seemed to be limited in our patient population because of the large number of intermediate results. Copyright (C) 2000 Elsevier Science Inc.
AB - Although there are many reports of the high diagnostic accuracy of commercially available serologic kits for Helicobacter pylori infection in Western countries, they rarely has been investigated in oriental population. Accordingly we examined their usefulness in 492 Japanese patients with dyspeptic symptoms. Diagnostic accuracy of 4 imported serologic kits (HEL-p TEST(TM), HM CAP(TM), G.A.P IgG(TM), Helico G2(TM)) was investigated using the 13C-urea breath test as the gold standard. When intermediate results were excluded, the sensitivity, specificity and accuracy of these serologic tests ranged from 88.6% to 97.8%, 67.9% to 85.9%, and 87.9% to 91.4%, respectively, which were comparable with reported median accuracy in the Western population. However, there were many intermediate results in these tests, ranging from 5.3% to 23.0%. Their usefulness seemed to be limited in our patient population because of the large number of intermediate results. Copyright (C) 2000 Elsevier Science Inc.
KW - Breath test
KW - ELISA
KW - GAP IgG
KW - HeL p
KW - Helico G2
KW - HM CAP
UR - http://www.scopus.com/inward/record.url?scp=0033972992&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033972992&partnerID=8YFLogxK
U2 - 10.1016/S0732-8893(99)00143-1
DO - 10.1016/S0732-8893(99)00143-1
M3 - Article
C2 - 10705050
AN - SCOPUS:0033972992
VL - 36
SP - 95
EP - 99
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
SN - 0732-8893
IS - 2
ER -