Insufficient diagnostic accuracy of imported serological kits for Helicobacter pylori infection in Japanese population

Hiroto Miwa, Shogo Kikuchi, Keiichi Ohtaka, Osamu Kobayashi, Atsushi Ogihara, Mariko Hojo, Akihito Nagahara, Nobuhiro Sato

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Although there are many reports of the high diagnostic accuracy of commercially available serologic kits for Helicobacter pylori infection in Western countries, they rarely has been investigated in oriental population. Accordingly we examined their usefulness in 492 Japanese patients with dyspeptic symptoms. Diagnostic accuracy of 4 imported serologic kits (HEL-p TEST(TM), HM CAP(TM), G.A.P IgG(TM), Helico G2(TM)) was investigated using the 13C-urea breath test as the gold standard. When intermediate results were excluded, the sensitivity, specificity and accuracy of these serologic tests ranged from 88.6% to 97.8%, 67.9% to 85.9%, and 87.9% to 91.4%, respectively, which were comparable with reported median accuracy in the Western population. However, there were many intermediate results in these tests, ranging from 5.3% to 23.0%. Their usefulness seemed to be limited in our patient population because of the large number of intermediate results. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume36
Issue number2
DOIs
Publication statusPublished - 2000 Feb 1

Keywords

  • Breath test
  • ELISA
  • GAP IgG
  • HM CAP
  • HeL p
  • Helico G2

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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