Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance

Teru Kanda, Naoki Horikoshi, Takayuki Murata, Daisuke Kawashima, Atsuko Sugimoto, Yohei Narita, Hitoshi Kurumizaka, Tatsuya Tsurumi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Epstein-Barr virus episomes piggyback onto cellular chromosomes in latently infected cells. Results: EBNA1 was functionally sound even when arginines within its chromosome binding domains were replaced with lysines. Conclusion: The basic nature of the domains is critically important for the chromosome binding. Significance: Learning how EBNA1 attaches to chromosomes is crucial for understanding the mechanism of stable maintenance of viral episomes.

Original languageEnglish
Pages (from-to)24189-24199
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
Publication statusPublished - 2013 Aug 16

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ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Kanda, T., Horikoshi, N., Murata, T., Kawashima, D., Sugimoto, A., Narita, Y., Kurumizaka, H., & Tsurumi, T. (2013). Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance. Journal of Biological Chemistry, 288(33), 24189-24199. https://doi.org/10.1074/jbc.M113.491167