Interaction between novel oscillation within the ventromedial hypothalamus and the sympathetic nervous system

Kamon Iigaya, Shuntaro Okazaki, Yoshino Minoura, Hiroshi Onimaru

    Research output: Contribution to journalArticle

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    Abstract

    The ventromedial hypothalamus (VMH) is known to play an important role in feeding behavior and the control of sympathetic nerve activity (SNA). We report the identification of novel neuron groups that showed oscillations on both sides of the VMH in hypothalamus slice preparations from juvenile rats of postnatal days 5–14. We detected spontaneous rhythmic burst activity with a frequency of around 0.06 Hz typically in the dorsolateral region of the VMH (i.e., VMH oscillation) using optical recordings (voltage and calcium imaging), field potential recordings and intracellular membrane potential recordings. The oscillation was also confirmed after isolation of the VMH from other hypothalamic structures. The frequency of oscillation was increased by lowering the glucose concentration of the superfusate. To evaluate the relation between VMH oscillation and SNA, we simultaneously recorded VMH oscillation, SNA from the thoracic sympathetic nerve trunk and phrenic nerve discharge (Phr) in the decerebrate and arterially perfused in situ preparation from juvenile rats of postnatal days 5–11. Power spectral analysis in the arterially perfused in situ rat preparation revealed similar peak values to those of slice preparations within the low-frequency range between the VMH oscillation and sympathetic nerve trunk activity. In addition, we analyzed cross-correlations between the VMH, SNA and Phr. The results revealed that a predominant positive correlation of the VMH activity with the SNA existed with an average time lag of 2.4 s, suggesting the presence of functional couplings between the VMH and SNA (and respiratory center) in the lower brainstem and spinal cord. We hypothesize that the VMH oscillation might be involved in low-frequency modulation of the SNA.

    Original languageEnglish
    Pages (from-to)213-221
    Number of pages9
    JournalNeuroscience
    Volume343
    DOIs
    Publication statusPublished - 2017 Feb 20

    Fingerprint

    Sympathetic Nervous System
    Hypothalamus
    Thoracic Nerves
    Respiratory Center
    Intracellular Membranes
    Phrenic Nerve
    Behavior Control
    Feeding Behavior
    Membrane Potentials
    Brain Stem
    Spinal Cord

    Keywords

    • oscillation
    • sympathetic nerve activity
    • ventromedial hypothalamus

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Interaction between novel oscillation within the ventromedial hypothalamus and the sympathetic nervous system. / Iigaya, Kamon; Okazaki, Shuntaro; Minoura, Yoshino; Onimaru, Hiroshi.

    In: Neuroscience, Vol. 343, 20.02.2017, p. 213-221.

    Research output: Contribution to journalArticle

    Iigaya, Kamon ; Okazaki, Shuntaro ; Minoura, Yoshino ; Onimaru, Hiroshi. / Interaction between novel oscillation within the ventromedial hypothalamus and the sympathetic nervous system. In: Neuroscience. 2017 ; Vol. 343. pp. 213-221.
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