Interaction between the ventilatory and cerebrovascular responses to hypo- and hypercapnia at rest and during exercise

Shigehiko Ogoh, Naoyuki Hayashi, Masashi Inagaki, Philip N. Ainslie, Tadayoshi Miyamoto

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

Cerebrovascular reactivity to changes in the partial pressure of arterial carbon dioxide (Pa,CO2) via limiting changes in brain [H+] modulates ventilatory control. It remains unclear, however, how exercise-induced alterations in respiratory chemoreflex might influence cerebral blood flow (CBF), in particular the cerebrovascular reactivity to CO2. The respiratory chemoreflex system controlling ventilation consists of two subsystems: the central controller (controlling element), and peripheral plant (controlled element). In order to examine the effect of exercise-induced alterations in ventilatory chemoreflex on cerebrovascular CO2 reactivity, these two subsystems of the respiratory chemoreflex system and cerebral CO2 reactivity were evaluated (n = 7) by the administration of CO2 as well as by voluntary hypo- and hyperventilation at rest and during steady-state exercise. During exercise, in the central controller, the regression line for the Pa,CO2-minute ventilation relation shifted to higher and VE and Pa,CO2 with no change in gain (P = 0.84). The functional curve of the peripheral plant also reset rightward and upward during exercise. However, from rest to exercise, gain of the peripheral plant decreased, especially during the hypercapnic condition (-4.1 ± 0.8 to -2.0 ± 0.2 mmHg l-1 min-1, P = 0.01). Therefore, under hypercapnia, total respiratory loop gain was markedly reduced during exercise (-8.0 ± 2.3 to -3.5 ± 1.0 U, P = 0.02). In contrast, cerebrovascular CO2 reactivity at each condition, especially to hypercapnia, was increased during exercise (2.4 ± 0.2 to 2.8 ± 0.2% mmHg-1, P = 0.03). These findings indicate that, despite an attenuated chemoreflex system controlling ventilation, elevations in cerebrovascular reactivity might help maintain CO2 homeostasis in the brain during exercise.

Original languageEnglish
Pages (from-to)4327-4338
Number of pages12
JournalJournal of Physiology
Volume586
Issue number17
DOIs
Publication statusPublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Physiology

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