Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles

Nao Nishida-Aoki, Takahiro Ochiya*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Abstract MicroRNAs (miRNAs) exhibit many functions in biological activities. Recent studies have shown that miRNAs exist outside cells and are transferred between cells. Extracellular miRNAs are protected from ribonucleases found in body fluids through binding to specific proteins or by being encapsulated in lipid bilayer vesicles. Here, we review the mechanisms of the secretion and uptake as well as the functions of extracellular miRNAs, particularly those encapsulated in extracellular vesicles. Extracellular vesicles are related to cancer progression, and some miRNAs in extracellular vesicles are associated with cancer cells. We describe the transfer of cancer-related miRNAs between cancer cells and non-cancerous cells. Finally, we discuss the anticipated applications of miRNAs present in extracellular vesicles in diagnostics and therapeutics.

Original languageEnglish
Article number1811
Pages (from-to)1849-1861
Number of pages13
JournalCellular and Molecular Life Sciences
Volume72
Issue number10
DOIs
Publication statusPublished - 2015 May 1
Externally publishedYes

Keywords

  • Cancer
  • Cancer therapy
  • Exosome
  • Extracellular RNA
  • Extracellular vesicle (EV)
  • MicroRNA (miRNA)

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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