Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles

Nao Nishida-Aoki; Takahiro Ochiya

doi:10.1007/s00018-014-1811-0

Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles

Nao Nishida-Aoki, Takahiro Ochiya^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Abstract MicroRNAs (miRNAs) exhibit many functions in biological activities. Recent studies have shown that miRNAs exist outside cells and are transferred between cells. Extracellular miRNAs are protected from ribonucleases found in body fluids through binding to specific proteins or by being encapsulated in lipid bilayer vesicles. Here, we review the mechanisms of the secretion and uptake as well as the functions of extracellular miRNAs, particularly those encapsulated in extracellular vesicles. Extracellular vesicles are related to cancer progression, and some miRNAs in extracellular vesicles are associated with cancer cells. We describe the transfer of cancer-related miRNAs between cancer cells and non-cancerous cells. Finally, we discuss the anticipated applications of miRNAs present in extracellular vesicles in diagnostics and therapeutics.

Original language	English
Article number	1811
Pages (from-to)	1849-1861
Number of pages	13
Journal	Cellular and Molecular Life Sciences
Volume	72
Issue number	10
DOIs	https://doi.org/10.1007/s00018-014-1811-0
Publication status	Published - 2015 May 1
Externally published	Yes

Keywords

Cancer
Cancer therapy
Exosome
Extracellular RNA
Extracellular vesicle (EV)
MicroRNA (miRNA)

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Pharmacology
Cellular and Molecular Neuroscience
Cell Biology

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title = "Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles",

abstract = "Abstract MicroRNAs (miRNAs) exhibit many functions in biological activities. Recent studies have shown that miRNAs exist outside cells and are transferred between cells. Extracellular miRNAs are protected from ribonucleases found in body fluids through binding to specific proteins or by being encapsulated in lipid bilayer vesicles. Here, we review the mechanisms of the secretion and uptake as well as the functions of extracellular miRNAs, particularly those encapsulated in extracellular vesicles. Extracellular vesicles are related to cancer progression, and some miRNAs in extracellular vesicles are associated with cancer cells. We describe the transfer of cancer-related miRNAs between cancer cells and non-cancerous cells. Finally, we discuss the anticipated applications of miRNAs present in extracellular vesicles in diagnostics and therapeutics.",

keywords = "Cancer, Cancer therapy, Exosome, Extracellular RNA, Extracellular vesicle (EV), MicroRNA (miRNA)",

author = "Nao Nishida-Aoki and Takahiro Ochiya",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for the Third-Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labor, and Welfare, Japan; the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation; the New Energy and Industrial Technology Development Organization (NEDO); the Japan Society for the Promotion of Science through the Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program) initiated by the Council for Science and Technology Policy; and a Grant-in-Aid for JSPS Fellows (No. 269202). The authors declare that they have no competing interests. Publisher Copyright: {\textcopyright} The Author(s) 2015.",

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doi = "10.1007/s00018-014-1811-0",

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AU - Nishida-Aoki, Nao

AU - Ochiya, Takahiro

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for the Third-Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labor, and Welfare, Japan; the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation; the New Energy and Industrial Technology Development Organization (NEDO); the Japan Society for the Promotion of Science through the Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program) initiated by the Council for Science and Technology Policy; and a Grant-in-Aid for JSPS Fellows (No. 269202). The authors declare that they have no competing interests. Publisher Copyright: © The Author(s) 2015.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Abstract MicroRNAs (miRNAs) exhibit many functions in biological activities. Recent studies have shown that miRNAs exist outside cells and are transferred between cells. Extracellular miRNAs are protected from ribonucleases found in body fluids through binding to specific proteins or by being encapsulated in lipid bilayer vesicles. Here, we review the mechanisms of the secretion and uptake as well as the functions of extracellular miRNAs, particularly those encapsulated in extracellular vesicles. Extracellular vesicles are related to cancer progression, and some miRNAs in extracellular vesicles are associated with cancer cells. We describe the transfer of cancer-related miRNAs between cancer cells and non-cancerous cells. Finally, we discuss the anticipated applications of miRNAs present in extracellular vesicles in diagnostics and therapeutics.

AB - Abstract MicroRNAs (miRNAs) exhibit many functions in biological activities. Recent studies have shown that miRNAs exist outside cells and are transferred between cells. Extracellular miRNAs are protected from ribonucleases found in body fluids through binding to specific proteins or by being encapsulated in lipid bilayer vesicles. Here, we review the mechanisms of the secretion and uptake as well as the functions of extracellular miRNAs, particularly those encapsulated in extracellular vesicles. Extracellular vesicles are related to cancer progression, and some miRNAs in extracellular vesicles are associated with cancer cells. We describe the transfer of cancer-related miRNAs between cancer cells and non-cancerous cells. Finally, we discuss the anticipated applications of miRNAs present in extracellular vesicles in diagnostics and therapeutics.

KW - Cancer

KW - Cancer therapy

KW - Exosome

KW - Extracellular RNA

KW - Extracellular vesicle (EV)

KW - MicroRNA (miRNA)

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Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles

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ASJC Scopus subject areas

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