Interactions of gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH) in birds and mammals

George E. Bentley, Lance J. Kriegsfeld, Tomohiro Osugi, Kazuyoshi Ukena, Sara O'Brien, Nicole Perfito, Ignacio T. Moore, Kazuyoshi Tsutsui, John C. Wingfield

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Gonadotropin-releasing hormone (GnRH) regulates secretion of both of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone. Thus, it is a key hormone for vertebrate reproduction. GnRH was considered to be unusual among hypothalamic neuropeptides in that it appeared to have no direct antagonist, although some neurochemicals and peripheral hormones (opiates, GABA, gonadal steroids, inhibin) can modulate gonadotropin release to a degree. Five years ago, a vertebrate hypothalamic neuropeptide that inhibited pituitary gonadotropin release in a dose-dependent manner was discovered in quail by Tsutsui et al. (2000. Biochem Biophys Res Commun 275:661-667). We now know that this inhibitory peptide, named gonadotropin-inhibitory hormone, or GnIH, is a regulator of gonadotropin release in vitro and in vivo. Its discovery has opened the door to an entirely new line of research within the realm of reproductive biology. In our collaborative studies, we have begun to elucidate the manner in which GnIH interacts with GnRH to time release of gonadotropins and thus time reproductive activity in birds and mammals. This paper reviews the distribution of GnIH in songbirds relative to GnRHs, and our findings on its modes of action in vitro and in vivo, based on laboratory and field studies. These data are simultaneously compared with our findings in mammals, highlighting how the use of different model species within different vertebrate classes can be a useful approach to identify the conserved actions of this novel neuropeptide, along with its potential importance to vertebrate reproduction.

Original languageEnglish
Pages (from-to)807-814
Number of pages8
JournalJournal of Experimental Zoology Part A: Comparative Experimental Biology
Volume305
Issue number9
DOIs
Publication statusPublished - 2006 Sep 1
Externally publishedYes

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gonadotropin-releasing hormone
gonadotropins
gonadotropin release
hormones
mammals
birds
neuropeptides
vertebrates
pituitary gonadotropins
inhibin
hormone secretion
follicle-stimulating hormone
songbirds
luteinizing hormone
quails
steroids
antagonists
mechanism of action
peptides
Biological Sciences

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Interactions of gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH) in birds and mammals. / Bentley, George E.; Kriegsfeld, Lance J.; Osugi, Tomohiro; Ukena, Kazuyoshi; O'Brien, Sara; Perfito, Nicole; Moore, Ignacio T.; Tsutsui, Kazuyoshi; Wingfield, John C.

In: Journal of Experimental Zoology Part A: Comparative Experimental Biology, Vol. 305, No. 9, 01.09.2006, p. 807-814.

Research output: Contribution to journalArticle

Bentley, George E. ; Kriegsfeld, Lance J. ; Osugi, Tomohiro ; Ukena, Kazuyoshi ; O'Brien, Sara ; Perfito, Nicole ; Moore, Ignacio T. ; Tsutsui, Kazuyoshi ; Wingfield, John C. / Interactions of gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH) in birds and mammals. In: Journal of Experimental Zoology Part A: Comparative Experimental Biology. 2006 ; Vol. 305, No. 9. pp. 807-814.
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