Interleukin-1β and interleukin-6 affect electrophysiological properties of thalamic relay cells

Vinicius Nikolaos Samios, Takafumi Inoue

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

By acknowledging the relation between brain and body in health and disease, inflammatory processes may play a key role in this reciprocal relation. Pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-6 (IL-6) are some of the agents involved in those processes. What exactly is their role in the CNS however is not that clear so far. To address the question of how pro-inflammatory cytokines may affect information processing at the cellular and molecular levels, relay neurons in the thalamic dorsal lateral geniculate nucleus in mouse brain slices were exposed to those cytokines and studied with the patch-clamp technique. IL-1β promoted hyperpolarization of the resting membrane potential (Vrest), decrease of input resistance (Rin), decrease of Ih rectification, decrease in action potential (AP) threshold and decrease in the number of APs in low threshold calcium spike (LTS) bursts, while IL-6 promoted decrease of Rin and decrease in the number of APs in LTS bursts. Computer simulations provided candidates for ionic conductance affected by those cytokines. Collectively, these findings demonstrate that IL-1β and IL-6 have modulatory effects on electrophysiological properties of thalamic neurons, implying that the thalamic functions may be affected by systemic disorders that present with high levels of those cytokines.

Original languageEnglish
Pages (from-to)16-25
Number of pages10
JournalNeuroscience Research
Volume87
Issue numberC
DOIs
Publication statusPublished - 2014

Keywords

  • IL-1β
  • IL-6
  • Interleukin
  • Patch-clamp
  • Thalamic relay cell

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Interleukin-1β and interleukin-6 affect electrophysiological properties of thalamic relay cells'. Together they form a unique fingerprint.

Cite this