Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats

Megumi Akiyoshi*, Yasutake Shimizu, Masayuki Saito

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


To clarify effects of interleukin-1 on sympathetic nerve activity, norepinephrine turnover in various organs was assessed in rats after intraperitoneal injection of recombinant human interleukin-1β. Interleukin-1 administration increased norepinephrine turnover in the spleen, lung and hypothalamus without appreciable effect in the heart, liver, submandibular gland, thymus, pancreas, brown adipose tissue and medulla oblongata. Similar changes in norepinephrine turnover were also found after the administration of bacterial endotoxin. It was concluded that interleukin-1 activates the sympathetic nerves specifically in the spleen and lung.

Original languageEnglish
Pages (from-to)1266-1270
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - 1990 Dec 31
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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