Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats

Megumi Akiyoshi, Yasutake Shimizu, Masayuki Saito

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

To clarify effects of interleukin-1 on sympathetic nerve activity, norepinephrine turnover in various organs was assessed in rats after intraperitoneal injection of recombinant human interleukin-1β. Interleukin-1 administration increased norepinephrine turnover in the spleen, lung and hypothalamus without appreciable effect in the heart, liver, submandibular gland, thymus, pancreas, brown adipose tissue and medulla oblongata. Similar changes in norepinephrine turnover were also found after the administration of bacterial endotoxin. It was concluded that interleukin-1 activates the sympathetic nerves specifically in the spleen and lung.

Original languageEnglish
Pages (from-to)1266-1270
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume173
Issue number3
DOIs
Publication statusPublished - 1990 Dec 31
Externally publishedYes

Fingerprint

Interleukin-1
Rats
Norepinephrine
Spleen
Lung
Thymus
Medulla Oblongata
Brown Adipose Tissue
Submandibular Gland
Intraperitoneal Injections
Endotoxins
Liver
Thymus Gland
Hypothalamus
Pancreas
Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats. / Akiyoshi, Megumi; Shimizu, Yasutake; Saito, Masayuki.

In: Biochemical and Biophysical Research Communications, Vol. 173, No. 3, 31.12.1990, p. 1266-1270.

Research output: Contribution to journalArticle

Akiyoshi, Megumi ; Shimizu, Yasutake ; Saito, Masayuki. / Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats. In: Biochemical and Biophysical Research Communications. 1990 ; Vol. 173, No. 3. pp. 1266-1270.
@article{f6afd60ca72e4939951162d6e1daaeae,
title = "Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats",
abstract = "To clarify effects of interleukin-1 on sympathetic nerve activity, norepinephrine turnover in various organs was assessed in rats after intraperitoneal injection of recombinant human interleukin-1β. Interleukin-1 administration increased norepinephrine turnover in the spleen, lung and hypothalamus without appreciable effect in the heart, liver, submandibular gland, thymus, pancreas, brown adipose tissue and medulla oblongata. Similar changes in norepinephrine turnover were also found after the administration of bacterial endotoxin. It was concluded that interleukin-1 activates the sympathetic nerves specifically in the spleen and lung.",
author = "Megumi Akiyoshi and Yasutake Shimizu and Masayuki Saito",
year = "1990",
month = "12",
day = "31",
doi = "10.1016/S0006-291X(05)80923-4",
language = "English",
volume = "173",
pages = "1266--1270",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats

AU - Akiyoshi, Megumi

AU - Shimizu, Yasutake

AU - Saito, Masayuki

PY - 1990/12/31

Y1 - 1990/12/31

N2 - To clarify effects of interleukin-1 on sympathetic nerve activity, norepinephrine turnover in various organs was assessed in rats after intraperitoneal injection of recombinant human interleukin-1β. Interleukin-1 administration increased norepinephrine turnover in the spleen, lung and hypothalamus without appreciable effect in the heart, liver, submandibular gland, thymus, pancreas, brown adipose tissue and medulla oblongata. Similar changes in norepinephrine turnover were also found after the administration of bacterial endotoxin. It was concluded that interleukin-1 activates the sympathetic nerves specifically in the spleen and lung.

AB - To clarify effects of interleukin-1 on sympathetic nerve activity, norepinephrine turnover in various organs was assessed in rats after intraperitoneal injection of recombinant human interleukin-1β. Interleukin-1 administration increased norepinephrine turnover in the spleen, lung and hypothalamus without appreciable effect in the heart, liver, submandibular gland, thymus, pancreas, brown adipose tissue and medulla oblongata. Similar changes in norepinephrine turnover were also found after the administration of bacterial endotoxin. It was concluded that interleukin-1 activates the sympathetic nerves specifically in the spleen and lung.

UR - http://www.scopus.com/inward/record.url?scp=0025541827&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025541827&partnerID=8YFLogxK

U2 - 10.1016/S0006-291X(05)80923-4

DO - 10.1016/S0006-291X(05)80923-4

M3 - Article

C2 - 2268328

AN - SCOPUS:0025541827

VL - 173

SP - 1266

EP - 1270

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -