TY - JOUR
T1 - Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats
AU - Akiyoshi, Megumi
AU - Shimizu, Yasutake
AU - Saito, Masayuki
PY - 1990/12/31
Y1 - 1990/12/31
N2 - To clarify effects of interleukin-1 on sympathetic nerve activity, norepinephrine turnover in various organs was assessed in rats after intraperitoneal injection of recombinant human interleukin-1β. Interleukin-1 administration increased norepinephrine turnover in the spleen, lung and hypothalamus without appreciable effect in the heart, liver, submandibular gland, thymus, pancreas, brown adipose tissue and medulla oblongata. Similar changes in norepinephrine turnover were also found after the administration of bacterial endotoxin. It was concluded that interleukin-1 activates the sympathetic nerves specifically in the spleen and lung.
AB - To clarify effects of interleukin-1 on sympathetic nerve activity, norepinephrine turnover in various organs was assessed in rats after intraperitoneal injection of recombinant human interleukin-1β. Interleukin-1 administration increased norepinephrine turnover in the spleen, lung and hypothalamus without appreciable effect in the heart, liver, submandibular gland, thymus, pancreas, brown adipose tissue and medulla oblongata. Similar changes in norepinephrine turnover were also found after the administration of bacterial endotoxin. It was concluded that interleukin-1 activates the sympathetic nerves specifically in the spleen and lung.
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U2 - 10.1016/S0006-291X(05)80923-4
DO - 10.1016/S0006-291X(05)80923-4
M3 - Article
C2 - 2268328
AN - SCOPUS:0025541827
SN - 0006-291X
VL - 173
SP - 1266
EP - 1270
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -