Intermolecular interactions of lithocholic acid derivatives with phospholipid as bilayer membrane

Zi Chen Li, Fu Mian Li, Shinya Arase, Shinji Takeoka, Eishun Tsuchida

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Three single chain lithocholic acid derivatives with a steroidal moiety in the center of the hydrocarbon chain and two head groups at both ends of the chain were synthesized and characterized. Due to their high compatibility with phospholipids, they can be incorporated homogeneously into the phospholipid bilayer membrane. The resulting mixed vesicles showed high stability against aggregation by monitoring the turbidity change in the vesicle suspensions. The entire membrane-spanning packing thus locates the steroidal moiety at the center of the bilayer. The interaction of the steroidal moiety with lipid molecules at the center of the bilayer resulted in higher mobility of lipid molecules below the Tc of the host phospholipid membrane as clarified by temperature-dependent 1H NMR, fluorescence depolarization anisotropy, and differential scanning calorimetry (DSC). The results were compared with those of cholesterol, whose steroidal moiety is located near the surface of the membrane.

    Original languageEnglish
    Pages (from-to)3161-3166
    Number of pages6
    JournalLangmuir
    Volume11
    Issue number8
    Publication statusPublished - 1995

    Fingerprint

    Lithocholic Acid
    Phospholipids
    membranes
    Derivatives
    Membranes
    acids
    Acids
    Lipids
    lipids
    interactions
    Molecules
    turbidity
    Cholesterol
    cholesterol
    Depolarization
    Turbidity
    Hydrocarbons
    depolarization
    compatibility
    molecules

    ASJC Scopus subject areas

    • Physical and Theoretical Chemistry
    • Colloid and Surface Chemistry

    Cite this

    Intermolecular interactions of lithocholic acid derivatives with phospholipid as bilayer membrane. / Li, Zi Chen; Li, Fu Mian; Arase, Shinya; Takeoka, Shinji; Tsuchida, Eishun.

    In: Langmuir, Vol. 11, No. 8, 1995, p. 3161-3166.

    Research output: Contribution to journalArticle

    Li, ZC, Li, FM, Arase, S, Takeoka, S & Tsuchida, E 1995, 'Intermolecular interactions of lithocholic acid derivatives with phospholipid as bilayer membrane', Langmuir, vol. 11, no. 8, pp. 3161-3166.
    Li, Zi Chen ; Li, Fu Mian ; Arase, Shinya ; Takeoka, Shinji ; Tsuchida, Eishun. / Intermolecular interactions of lithocholic acid derivatives with phospholipid as bilayer membrane. In: Langmuir. 1995 ; Vol. 11, No. 8. pp. 3161-3166.
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