Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development

Kohta Ikegami, Jun Ohgane, Satoshi Tanaka, Shintaro Yagi, Kunio Shiota*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

95 Citations (Scopus)


Genes constitute only a small proportion of the mammalian genome, the majority of which is composed of non-genic repetitive elements including interspersed repeats and satellites. A unique feature of the mammalian genome is that there are numerous tissue-dependent, differentially methylated regions (T-DMRs) in the non-repetitive sequences, which include genes and their regulatory elements. The epigenetic status of T-DMRs varies from that of repetitive elements and constitutes the DNA methylation profile genome-wide. Since the DNA methylation profile is specific to each cell and tissue type, much like a fingerprint, it can be used as a means of identification. The formation of DNA methylation profiles is the basis for cell differentiation and development in mammals. The epigenetic status of each T-DMR is regulated by the interplay between DNA methyltransferases, histone modification enzymes, histone subtypes, non-histone nuclear proteins and non-coding RNAs. In this review, we will discuss how these epigenetic factors cooperate to establish cell- and tissue-specific DNA methylation profiles.

Original languageEnglish
Pages (from-to)203-214
Number of pages12
JournalInternational Journal of Developmental Biology
Issue number2-3
Publication statusPublished - 2009
Externally publishedYes


  • Chromatin remodeling
  • DNA methylation
  • Epigenetics
  • Histone modification
  • T-DMR

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Medicine(all)


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