Intra-aneurysmal hemodynamics during the growth of an unruptured aneurysm: In vitro study using longitudinal CT angiogram database

Satoshi Tateshima, K. Tanishita, H. Omura, J. P. Villablanca, F. Vinuela

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: The role of blood-flow biomechanics on the size, morphology, and growth of cerebral aneurysms is poorly known. The purpose of this study was to evaluate intra-aneurysmal hemodynamics before and after aneurysm growth. MATERIALS AND METHODS: A flow-simulation study was performed in a middle cerebral artery (MCA) aneurysm with a bleb that grew after 1-year follow-up. Geometrically realistic in vitro models before and after aneurysm growth were constructed on the basis of CT angiograms. Blood-flow velocity, vorticity, and wall shear stress were obtained by using particle imaging velocimetry and laser Doppler velocimetry. RESULTS: No significant quantitative differences were noted among the overall flow structures before and after aneurysm growth, with the exception of less vorticity in the bleb after aneurysm growth. A circulating flow pattern was seen within the aneurysm domes. A blood-flow separation was observed at the margins of the bleb. No impingement of inward flow into the enlarging bleb was noted. Before the aneurysm growth, the wall shear stress was high at the aneurysm neck and also at the margin of the bleb. The value of wall shear stress decreased in the deeper part of the bleb. This value decreased even more after the aneurysm growth. CONCLUSIONS: Intra-aneurysmal hemodynamic structures before and after the growth of an MCA aneurysm were compared. Further investigation with a similar approach is mandatory to obtain a firm conclusion.

Original languageEnglish
Pages (from-to)622-627
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume28
Issue number4
Publication statusPublished - 2007 Apr
Externally publishedYes

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Aneurysm
Longitudinal Studies
Angiography
Blister
Hemodynamics
Databases
Growth
Intracranial Aneurysm
Laser-Doppler Flowmetry
Blood Flow Velocity
In Vitro Techniques
Rheology
Biomechanical Phenomena

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Intra-aneurysmal hemodynamics during the growth of an unruptured aneurysm : In vitro study using longitudinal CT angiogram database. / Tateshima, Satoshi; Tanishita, K.; Omura, H.; Villablanca, J. P.; Vinuela, F.

In: American Journal of Neuroradiology, Vol. 28, No. 4, 04.2007, p. 622-627.

Research output: Contribution to journalArticle

Tateshima, Satoshi ; Tanishita, K. ; Omura, H. ; Villablanca, J. P. ; Vinuela, F. / Intra-aneurysmal hemodynamics during the growth of an unruptured aneurysm : In vitro study using longitudinal CT angiogram database. In: American Journal of Neuroradiology. 2007 ; Vol. 28, No. 4. pp. 622-627.
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