Intraaneurysmal flow dynamics study featuring an acrylic aneurysm model manufactured using a computerized tomography angiogram as a mold

S. Tateshima, Y. Murayama, J. P. Villablanca, T. Morino, H. Takahashi, T. Yamauchi, K. Tanishita, F. Viñuela

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Object. To obtain precise flow profiles in patients' aneurysms, the authors developed a new in vitro study method featuring an aneurysm model manufactured using three-dimensional computerized tomography (3D CT) angiography. Methods. A clear acrylic basilar artery (BA) tip aneurysm model manufactured from a patient's 3D CT angiogram was used to analyze flow modifications during one cardiac cycle. Stereolithography was utilized to create the aneurysm model. Three-dimensional flow profiles within the aneurysm model were obtained from velocity measurements by using laser Doppler velocimetry. The aneurysm inflow/outflow zones changed dynamically in their location, size of their cross-sectional area, and also in their shapes over one cardiac cycle. The flow velocity at the inflow zone was 16.8 to 81.9% of the highest axial velocity in the BA with a pulsatility index (PI) of 1.1. The flow velocity at the outflow zone was 16.8 to 34.3% of the highest axial velocity of the BA, with a PI of 0.68. The shear stress along the walls of the aneurysm was calculated from the fluid velocity measured at a distance of 0.5 mm from the wall. The highest value of shear stress was observed at the bleb of the aneurysm. Conclusions. This clear acrylic model of a BA tip aneurysm manufactured using a CT angiogram allowed qualitative and quantitative analysis of its flow during a cardiac cycle. Accumulated knowledge from this type of study may reveal pertinent information about aneurysmal flow dynamics that will help practitioners understand the relationship among anatomy, flow dynamics, and the natural history of aneurysms.

Original languageEnglish
Pages (from-to)1020-1027
Number of pages8
JournalJournal of Neurosurgery
Volume95
Issue number6
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Aneurysm
Angiography
Fungi
Tomography
Basilar Artery
Intracranial Aneurysm
Laser-Doppler Flowmetry
Blister
Anatomy

Keywords

  • Basilar artery tip aneurysm
  • Blood flow velocity
  • Cerebral aneurysm
  • Flow dynamics
  • Shear stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Tateshima, S., Murayama, Y., Villablanca, J. P., Morino, T., Takahashi, H., Yamauchi, T., ... Viñuela, F. (2001). Intraaneurysmal flow dynamics study featuring an acrylic aneurysm model manufactured using a computerized tomography angiogram as a mold. Journal of Neurosurgery, 95(6), 1020-1027.

Intraaneurysmal flow dynamics study featuring an acrylic aneurysm model manufactured using a computerized tomography angiogram as a mold. / Tateshima, S.; Murayama, Y.; Villablanca, J. P.; Morino, T.; Takahashi, H.; Yamauchi, T.; Tanishita, K.; Viñuela, F.

In: Journal of Neurosurgery, Vol. 95, No. 6, 2001, p. 1020-1027.

Research output: Contribution to journalArticle

Tateshima, S, Murayama, Y, Villablanca, JP, Morino, T, Takahashi, H, Yamauchi, T, Tanishita, K & Viñuela, F 2001, 'Intraaneurysmal flow dynamics study featuring an acrylic aneurysm model manufactured using a computerized tomography angiogram as a mold', Journal of Neurosurgery, vol. 95, no. 6, pp. 1020-1027.
Tateshima S, Murayama Y, Villablanca JP, Morino T, Takahashi H, Yamauchi T et al. Intraaneurysmal flow dynamics study featuring an acrylic aneurysm model manufactured using a computerized tomography angiogram as a mold. Journal of Neurosurgery. 2001;95(6):1020-1027.
Tateshima, S. ; Murayama, Y. ; Villablanca, J. P. ; Morino, T. ; Takahashi, H. ; Yamauchi, T. ; Tanishita, K. ; Viñuela, F. / Intraaneurysmal flow dynamics study featuring an acrylic aneurysm model manufactured using a computerized tomography angiogram as a mold. In: Journal of Neurosurgery. 2001 ; Vol. 95, No. 6. pp. 1020-1027.
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abstract = "Object. To obtain precise flow profiles in patients' aneurysms, the authors developed a new in vitro study method featuring an aneurysm model manufactured using three-dimensional computerized tomography (3D CT) angiography. Methods. A clear acrylic basilar artery (BA) tip aneurysm model manufactured from a patient's 3D CT angiogram was used to analyze flow modifications during one cardiac cycle. Stereolithography was utilized to create the aneurysm model. Three-dimensional flow profiles within the aneurysm model were obtained from velocity measurements by using laser Doppler velocimetry. The aneurysm inflow/outflow zones changed dynamically in their location, size of their cross-sectional area, and also in their shapes over one cardiac cycle. The flow velocity at the inflow zone was 16.8 to 81.9{\%} of the highest axial velocity in the BA with a pulsatility index (PI) of 1.1. The flow velocity at the outflow zone was 16.8 to 34.3{\%} of the highest axial velocity of the BA, with a PI of 0.68. The shear stress along the walls of the aneurysm was calculated from the fluid velocity measured at a distance of 0.5 mm from the wall. The highest value of shear stress was observed at the bleb of the aneurysm. Conclusions. This clear acrylic model of a BA tip aneurysm manufactured using a CT angiogram allowed qualitative and quantitative analysis of its flow during a cardiac cycle. Accumulated knowledge from this type of study may reveal pertinent information about aneurysmal flow dynamics that will help practitioners understand the relationship among anatomy, flow dynamics, and the natural history of aneurysms.",
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AU - Tateshima, S.

AU - Murayama, Y.

AU - Villablanca, J. P.

AU - Morino, T.

AU - Takahashi, H.

AU - Yamauchi, T.

AU - Tanishita, K.

AU - Viñuela, F.

PY - 2001

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N2 - Object. To obtain precise flow profiles in patients' aneurysms, the authors developed a new in vitro study method featuring an aneurysm model manufactured using three-dimensional computerized tomography (3D CT) angiography. Methods. A clear acrylic basilar artery (BA) tip aneurysm model manufactured from a patient's 3D CT angiogram was used to analyze flow modifications during one cardiac cycle. Stereolithography was utilized to create the aneurysm model. Three-dimensional flow profiles within the aneurysm model were obtained from velocity measurements by using laser Doppler velocimetry. The aneurysm inflow/outflow zones changed dynamically in their location, size of their cross-sectional area, and also in their shapes over one cardiac cycle. The flow velocity at the inflow zone was 16.8 to 81.9% of the highest axial velocity in the BA with a pulsatility index (PI) of 1.1. The flow velocity at the outflow zone was 16.8 to 34.3% of the highest axial velocity of the BA, with a PI of 0.68. The shear stress along the walls of the aneurysm was calculated from the fluid velocity measured at a distance of 0.5 mm from the wall. The highest value of shear stress was observed at the bleb of the aneurysm. Conclusions. This clear acrylic model of a BA tip aneurysm manufactured using a CT angiogram allowed qualitative and quantitative analysis of its flow during a cardiac cycle. Accumulated knowledge from this type of study may reveal pertinent information about aneurysmal flow dynamics that will help practitioners understand the relationship among anatomy, flow dynamics, and the natural history of aneurysms.

AB - Object. To obtain precise flow profiles in patients' aneurysms, the authors developed a new in vitro study method featuring an aneurysm model manufactured using three-dimensional computerized tomography (3D CT) angiography. Methods. A clear acrylic basilar artery (BA) tip aneurysm model manufactured from a patient's 3D CT angiogram was used to analyze flow modifications during one cardiac cycle. Stereolithography was utilized to create the aneurysm model. Three-dimensional flow profiles within the aneurysm model were obtained from velocity measurements by using laser Doppler velocimetry. The aneurysm inflow/outflow zones changed dynamically in their location, size of their cross-sectional area, and also in their shapes over one cardiac cycle. The flow velocity at the inflow zone was 16.8 to 81.9% of the highest axial velocity in the BA with a pulsatility index (PI) of 1.1. The flow velocity at the outflow zone was 16.8 to 34.3% of the highest axial velocity of the BA, with a PI of 0.68. The shear stress along the walls of the aneurysm was calculated from the fluid velocity measured at a distance of 0.5 mm from the wall. The highest value of shear stress was observed at the bleb of the aneurysm. Conclusions. This clear acrylic model of a BA tip aneurysm manufactured using a CT angiogram allowed qualitative and quantitative analysis of its flow during a cardiac cycle. Accumulated knowledge from this type of study may reveal pertinent information about aneurysmal flow dynamics that will help practitioners understand the relationship among anatomy, flow dynamics, and the natural history of aneurysms.

KW - Basilar artery tip aneurysm

KW - Blood flow velocity

KW - Cerebral aneurysm

KW - Flow dynamics

KW - Shear stress

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