Intracellular-to-total water ratio explains the variability of muscle strength dependence on the size of the lower leg in the elderly

Tsukasa Yoshida, Yosuke Yamada, Fumiko Tanaka, Takaki Yamagishi, Shigenobu Shibata, Yasuo Kawakami

Research output: Contribution to journalArticle

Abstract

Bioelectrical impedance spectroscopy (BIS) can assess intracellular water (ICW) and total water (TW) in limbs. This study aimed to examine whether BIS can explain a part of the inter-individual variation of the muscle size-strength relationship in older adults. We analyzed the data of 79 participants aged 64–86 years. The maximal voluntary isometric torques of dorsiflexion and plantar flexion on the right side were measured. The anterior and posterior muscle thickness (MT) in the right lower leg was assessed using ultrasonography. The length of the right lower leg (L) was measured, and the ICW-to-TW ratio (ICW/TW) in the right lower leg was obtained using BIS. The MT was multiplied by L to represent an index of muscle volume (MV). Correlation and stepwise regression analyses were performed. The anterior and posterior MT × L significantly and positively correlated with the muscle torque of dorsiflexion and plantar flexion (r = 0.710 and 0.649, respectively, P < 0.001). In the stepwise regression analyses, ICW/TW was selected as a significant predictor of muscle torque independent of MT × L (P < 0.05) for both dorsiflexion and plantar flexion. Electrical parameters of BIS (membrane capacitance, characteristics frequency, and phase angle) in the lower leg also significantly correlated with muscle torques. In addition, the skeletal muscle mass index (appendicular lean mass/height2) was also associated with ICW/TW (P < 0.001). The present results suggest that ICW/TW explains the interindividual variations of the muscle size-strength relationship.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalExperimental Gerontology
Volume113
DOIs
Publication statusPublished - 2018 Nov 1

Fingerprint

Muscle Strength
Muscle
Leg
Water
Dielectric Spectroscopy
Muscles
Acoustic impedance
Torque
Electric Impedance
Spectroscopy
Regression Analysis
Ultrasonography
Skeletal Muscle
Extremities
Capacitance
Membranes

Keywords

  • Heterogeneity
  • Muscle composition
  • Muscle quality
  • Sarcopenia
  • Skeletal muscle tissue
  • Specific torque
  • Water fraction

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

Cite this

Intracellular-to-total water ratio explains the variability of muscle strength dependence on the size of the lower leg in the elderly. / Yoshida, Tsukasa; Yamada, Yosuke; Tanaka, Fumiko; Yamagishi, Takaki; Shibata, Shigenobu; Kawakami, Yasuo.

In: Experimental Gerontology, Vol. 113, 01.11.2018, p. 120-127.

Research output: Contribution to journalArticle

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