Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses

Kaori Ono, Masako Tsukamoto-Yasui, Yoshiko Hara-Kimura, Naohiko Inoue, Yoshihito Nogusa, Yuki Okabe, Kei Nagashima, Fusao Kato

    Research output: Contribution to journalArticle

    61 Citations (Scopus)

    Abstract

    Ono K, Tsukamoto-Yasui M, Hara-Kimura Y, Inoue N, Nogusa Y, Okabe Y, Nagashima K, Kato F. Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses. J Appl Physiol 110: 789-798, 2011. First published November 11, 2010; doi:10.1152/japplphysiol.00128.2010.- The sympathetic thermoregulatory system controls the magnitude of adaptive thermogenesis in correspondence with the environmental temperature or the state of energy intake and plays a key role in determining the resultant energy storage. However, the nature of the trigger initiating this reflex arc remains to be determined. Here, using capsiate, a digestion-vulnerable capsaicin analog, we examined the involvement of specific activation of transient receptor potential (TRP) channels within the gastrointestinal tract in the thermogenic sympathetic system by measuring the efferent activity of the postganglionic sympathetic nerve innervating brown adipose tissue (BAT) in anesthetized rats. Intragastric administration of capsiate resulted in a time- and dose-dependent increase in integrated BAT sympathetic nerve activity (SNA) over 180 min, which was characterized by an emergence of sporadic high-activity phases composed of lowfrequency bursts. This increase in BAT SNA was abolished by blockade of TRP channels as well as of sympathetic ganglionic transmission and was inhibited by ablation of the gastrointestinal vagus nerve. The activation of SNA was delimited to BAT and did not occur in the heart or pancreas. These results point to a neural pathway enabling the selective activation of the central network regulating the BAT SNA in response to a specific stimulation of gastrointestinal TRP channels and offer important implications for understanding the dietary-dependent regulation of energy metabolism and control of obesity.

    Original languageEnglish
    Pages (from-to)789-798
    Number of pages10
    JournalJournal of Applied Physiology
    Volume110
    Issue number3
    DOIs
    Publication statusPublished - 2011 Mar 1

    Fingerprint

    Transient Receptor Potential Channels
    Brown Adipose Tissue
    Neural Pathways
    Vagus Nerve
    Thermogenesis
    Capsaicin
    Energy Intake
    Energy Metabolism
    Reflex
    Gastrointestinal Tract
    Pancreas
    Digestion
    Obesity
    capsiate
    Temperature

    Keywords

    • Brown adipose tissue
    • Capsaicin
    • Gastrointestinal tract
    • Obesity
    • Sympathetic nervous system
    • Thermogenesis

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)

    Cite this

    Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses. / Ono, Kaori; Tsukamoto-Yasui, Masako; Hara-Kimura, Yoshiko; Inoue, Naohiko; Nogusa, Yoshihito; Okabe, Yuki; Nagashima, Kei; Kato, Fusao.

    In: Journal of Applied Physiology, Vol. 110, No. 3, 01.03.2011, p. 789-798.

    Research output: Contribution to journalArticle

    Ono, Kaori ; Tsukamoto-Yasui, Masako ; Hara-Kimura, Yoshiko ; Inoue, Naohiko ; Nogusa, Yoshihito ; Okabe, Yuki ; Nagashima, Kei ; Kato, Fusao. / Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses. In: Journal of Applied Physiology. 2011 ; Vol. 110, No. 3. pp. 789-798.
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    AU - Tsukamoto-Yasui, Masako

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    AU - Inoue, Naohiko

    AU - Nogusa, Yoshihito

    AU - Okabe, Yuki

    AU - Nagashima, Kei

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