Intramolecular C-H Alkenylation of N-Alkynylindoles: Exo and Endo Selective Cyclization According to the Choice of Metal Catalyst

Takanori Shibata, Takumi Baba, Hideaki Takano, Stephen Kyalo Kanyiva

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The intramolecular reaction of 3-acetyl-N-alkynylindoles proceeded via C-H bond cleavage at the C2 position. Iridium and rhodium catalysts selectively promoted 6-exo-dig and 7-endo-dig cyclization, respectively, and N-fused tricyclic compounds were obtained.

Original languageEnglish
JournalAdvanced Synthesis and Catalysis
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Alkenylation
Iridium
Rhodium
Cyclization
Metals
Catalysts

Keywords

  • Alkenylation
  • C-H activation
  • Indoles
  • Iridium
  • Rhodium

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Cite this

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abstract = "The intramolecular reaction of 3-acetyl-N-alkynylindoles proceeded via C-H bond cleavage at the C2 position. Iridium and rhodium catalysts selectively promoted 6-exo-dig and 7-endo-dig cyclization, respectively, and N-fused tricyclic compounds were obtained.",
keywords = "Alkenylation, C-H activation, Indoles, Iridium, Rhodium",
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year = "2017",
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AU - Shibata, Takanori

AU - Baba, Takumi

AU - Takano, Hideaki

AU - Kanyiva, Stephen Kyalo

PY - 2017

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AB - The intramolecular reaction of 3-acetyl-N-alkynylindoles proceeded via C-H bond cleavage at the C2 position. Iridium and rhodium catalysts selectively promoted 6-exo-dig and 7-endo-dig cyclization, respectively, and N-fused tricyclic compounds were obtained.

KW - Alkenylation

KW - C-H activation

KW - Indoles

KW - Iridium

KW - Rhodium

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