Intramolecular C-H Alkenylation of N-Alkynylindoles: Exo and Endo Selective Cyclization According to the Choice of Metal Catalyst

Takanori Shibata; Takumi Baba; Hideaki Takano; Stephen Kyalo Kanyiva

doi:10.1002/adsc.201700107

Intramolecular C-H Alkenylation of N-Alkynylindoles: Exo and Endo Selective Cyclization According to the Choice of Metal Catalyst

Takanori Shibata^*, Takumi Baba, Hideaki Takano, Stephen Kyalo Kanyiva

^*Corresponding author for this work

Global Center for Science and Engineering

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The intramolecular reaction of 3-acetyl-N-alkynylindoles proceeded via C-H bond cleavage at the C2 position. Iridium and rhodium catalysts selectively promoted 6-exo-dig and 7-endo-dig cyclization, respectively, and N-fused tricyclic compounds were obtained.

Original language	English
Journal	Advanced Synthesis and Catalysis
DOIs	https://doi.org/10.1002/adsc.201700107
Publication status	Accepted/In press - 2017

Keywords

Alkenylation
C-H activation
Indoles
Iridium
Rhodium

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1002/adsc.201700107

Cite this

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title = "Intramolecular C-H Alkenylation of N-Alkynylindoles: Exo and Endo Selective Cyclization According to the Choice of Metal Catalyst",

abstract = "The intramolecular reaction of 3-acetyl-N-alkynylindoles proceeded via C-H bond cleavage at the C2 position. Iridium and rhodium catalysts selectively promoted 6-exo-dig and 7-endo-dig cyclization, respectively, and N-fused tricyclic compounds were obtained.",

keywords = "Alkenylation, C-H activation, Indoles, Iridium, Rhodium",

author = "Takanori Shibata and Takumi Baba and Hideaki Takano and Kanyiva, {Stephen Kyalo}",

year = "2017",

doi = "10.1002/adsc.201700107",

language = "English",

journal = "Advanced Synthesis and Catalysis",

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T1 - Intramolecular C-H Alkenylation of N-Alkynylindoles

T2 - Exo and Endo Selective Cyclization According to the Choice of Metal Catalyst

AU - Shibata, Takanori

AU - Baba, Takumi

AU - Takano, Hideaki

AU - Kanyiva, Stephen Kyalo

PY - 2017

Y1 - 2017

N2 - The intramolecular reaction of 3-acetyl-N-alkynylindoles proceeded via C-H bond cleavage at the C2 position. Iridium and rhodium catalysts selectively promoted 6-exo-dig and 7-endo-dig cyclization, respectively, and N-fused tricyclic compounds were obtained.

AB - The intramolecular reaction of 3-acetyl-N-alkynylindoles proceeded via C-H bond cleavage at the C2 position. Iridium and rhodium catalysts selectively promoted 6-exo-dig and 7-endo-dig cyclization, respectively, and N-fused tricyclic compounds were obtained.

KW - Alkenylation

KW - C-H activation

KW - Indoles

KW - Iridium

KW - Rhodium

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DO - 10.1002/adsc.201700107

M3 - Article

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JO - Advanced Synthesis and Catalysis

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ER -

Intramolecular C-H Alkenylation of N-Alkynylindoles: Exo and Endo Selective Cyclization According to the Choice of Metal Catalyst

Abstract

Keywords

ASJC Scopus subject areas

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