Intraoperative cortico-cortical evoked potentials for the evaluation of language function during brain tumor resection: Initial experience with 13 cases

Taiichi Saito, Manabu Tamura, Yoshihiro Muragaki, Takashi Maruyama, Yuichi Kubota, Satoko Fukuchi, Masayuki Nitta, Mikhail Chernov, Saori Okamoto, Kazuhiko Sugiyama, Kaoru Kurisu, Kuniyoshi L. Sakai, Yoshikazu Okada, Hiroshi Iseki

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    Abstract

    Methods. Intraoperative monitoring of CCEP was applied in 13 patients (mean age 34 ± 14 years) during the removal of neoplasms located within or close to language-related structures in the dominant cerebral hemisphere. For this purpose strip electrodes were positioned above the frontal language area (FLA) and temporal language area (TLA), which were identified with direct cortical stimulation and/or preliminary mapping with the use of implanted chronic subdural grid electrodes. The CCEP response was defined as the highest observed negative peak in either direction of stimulation. In 12 cases the tumor was resected during awake craniotomy.

    Results. An intraoperative CCEP response was not obtained in one case because of technical problems. In the other patients it was identified from the FLA during stimulation of the TLA (7 cases) and from the TLA during stimulation of the FLA (5 cases), with a mean peak latency of 83 ± 15 msec. During tumor resection the CCEP response was unchanged in 5 cases, decreased in 4, and disappeared in 3. Postoperatively, all 7 patients with a decreased or absent CCEP response after lesion removal experienced deterioration in speech function. In contrast, in 5 cases with an unchanged intraoperative CCEP response, speaking abilities after surgery were preserved at the preoperative level, except in one patient who experienced not dysphasia, but dysarthria due to pyramidal tract injury. This difference was statistically significant (p < 0.01). The time required to recover speech function was also significantly associated with the type of intraoperative change in CCEP recordings (p < 0.01) and was, on average, 1.8 ± 1.0, 5.5 ± 1.0, and 11.0 ± 3.6 months, respectively, if the response was unchanged, was decreased, or had disappeared.

    Conclusions. Monitoring CCEP is feasible during the resection of brain tumors affecting language-related cerebral structures. In the intraoperative evaluation of speech function, it can be a helpful adjunct or can be used in its direct assessment with cortical and subcortical mapping during awake craniotomy. It can also be used to predict the prognosis of language disorders after surgery and decide on the optimal resection of a neoplasm.

    Object. The objective in the present study was to evaluate the usefulness of cortico-cortical evoked potentials (CCEP) monitoring for the intraoperative assessment of speech function during resection of brain tumors.

    Original languageEnglish
    Pages (from-to)827-838
    Number of pages12
    JournalJournal of neurosurgery
    Volume121
    Issue number4
    DOIs
    Publication statusPublished - 2014 Oct 1

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    Keywords

    • Awake craniotomy
    • Brain tumor
    • Cortico-cortical evoked potentials
    • Diagnostic and operative techniques
    • Language function
    • Oncology
    • Surgery

    ASJC Scopus subject areas

    • Surgery
    • Clinical Neurology

    Cite this

    Saito, T., Tamura, M., Muragaki, Y., Maruyama, T., Kubota, Y., Fukuchi, S., Nitta, M., Chernov, M., Okamoto, S., Sugiyama, K., Kurisu, K., Sakai, K. L., Okada, Y., & Iseki, H. (2014). Intraoperative cortico-cortical evoked potentials for the evaluation of language function during brain tumor resection: Initial experience with 13 cases. Journal of neurosurgery, 121(4), 827-838. https://doi.org/10.3171/2014.4.JNS131195