Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence

Takehiro Ando, M. Noguch, K. Shimaya, K. Wang, E. Kobayashi, H. Liao, T. Maruyama, Y. Mulagaki, Hiroshi Iseki, I. Sakuma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A lightweight intraoperative spectrum measurement system for 5-ALA induced PpIX fluorescence was developed. The developed system includes a semiconductor LASER for excitation light (output light wavelength: 405nm), a CCD spectrometer, optical fiber coupled on lens system and PC. The first prototype device has a bundled fiber which contains 6 excitation fibers around one measurement fiber. The second one uses a dichroic mirror which reflects blue light (λ≤550nm) and transmits other wavelength. The third one contains not only a dichroic mirror but also a long path filter (cut on: λ=570nm) and has improved mechanical strength. The weight of the first and the prototype probe is 45g, and the external diameter is 11mm.. The weight of this probe is 25g and the external diameter is 18mm. The probes can be positioned manually and measure 5-ALA induced PpIX fluorescence.

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages754-757
Number of pages4
Volume19 IFMBE
DOIs
Publication statusPublished - 2008
Externally publishedYes
Event7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008 - Beijing
Duration: 2008 Apr 222008 Apr 25

Other

Other7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008
CityBeijing
Period08/4/2208/4/25

Fingerprint

Aminolevulinic Acid
Porphyrins
Tumors
Brain
Fluorescence
Acids
Fibers
Mirrors
Optical fiber coupling
Wavelength
Charge coupled devices
Strength of materials
Spectrometers
Lenses
Semiconductor materials

Keywords

  • 5-ALA
  • Brain tumor
  • Fluorescence measurement
  • Handheld device
  • Protoporphyrin IX

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Ando, T., Noguch, M., Shimaya, K., Wang, K., Kobayashi, E., Liao, H., ... Sakuma, I. (2008). Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence. In IFMBE Proceedings (Vol. 19 IFMBE, pp. 754-757) https://doi.org/10.1007/978-3-540-79039-6-186

Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence. / Ando, Takehiro; Noguch, M.; Shimaya, K.; Wang, K.; Kobayashi, E.; Liao, H.; Maruyama, T.; Mulagaki, Y.; Iseki, Hiroshi; Sakuma, I.

IFMBE Proceedings. Vol. 19 IFMBE 2008. p. 754-757.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ando, T, Noguch, M, Shimaya, K, Wang, K, Kobayashi, E, Liao, H, Maruyama, T, Mulagaki, Y, Iseki, H & Sakuma, I 2008, Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence. in IFMBE Proceedings. vol. 19 IFMBE, pp. 754-757, 7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008, Beijing, 08/4/22. https://doi.org/10.1007/978-3-540-79039-6-186
Ando T, Noguch M, Shimaya K, Wang K, Kobayashi E, Liao H et al. Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence. In IFMBE Proceedings. Vol. 19 IFMBE. 2008. p. 754-757 https://doi.org/10.1007/978-3-540-79039-6-186
Ando, Takehiro ; Noguch, M. ; Shimaya, K. ; Wang, K. ; Kobayashi, E. ; Liao, H. ; Maruyama, T. ; Mulagaki, Y. ; Iseki, Hiroshi ; Sakuma, I. / Intraoperative local demarcation system of brain tumor based on 5-aminolaevulinic acid induced porphyrin fluorescence. IFMBE Proceedings. Vol. 19 IFMBE 2008. pp. 754-757
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AU - Kobayashi, E.

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