Intrinsic DNA bends: An organizer of local chromatin structure for transcription

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

DNA with a curved trajectory of its helix axis is called bent DNA, or curved DNA. Interestingly, biologically important DNA regions often contain this structure, irrespective of the origin of DNA. In the last decade, considerable progress has been made in clarifying one role of bent DNA in prokaryotic transcription and its mechanism of action. However, the role of bent DNA in eukaryotic transcription remains unclear. Our recent study raises the possibility that bent DNA is implicated in the "functional packaging" of transcriptional regulatory regions into chromatin. In this article, I review recent progress in bent DNA research in eukaryotic transcription, and summarize the history of bent DNA research and several subjects relevant to this theme. Finally, I propose a hypothesis that bent DNA structures that mimic a negative supercoil, or have a right-handed superhelical writhe, organize local chromatin infrastructure to help the very first interaction between cis-acting DNA elements and activators that trigger transcription.

Original languageEnglish
Pages (from-to)708-715
Number of pages8
JournalBioEssays
Volume23
Issue number8
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Transcription
Chromatin
chromatin
transcription (genetics)
DNA
Nucleic Acid Regulatory Sequences
Product Packaging
Research
infrastructure
packaging
trajectories
mechanism of action
Packaging
History
Trajectories

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Intrinsic DNA bends : An organizer of local chromatin structure for transcription. / Ohyama, Takashi.

In: BioEssays, Vol. 23, No. 8, 2001, p. 708-715.

Research output: Contribution to journalArticle

@article{86ed64b12fad41708e08a374192a3980,
title = "Intrinsic DNA bends: An organizer of local chromatin structure for transcription",
abstract = "DNA with a curved trajectory of its helix axis is called bent DNA, or curved DNA. Interestingly, biologically important DNA regions often contain this structure, irrespective of the origin of DNA. In the last decade, considerable progress has been made in clarifying one role of bent DNA in prokaryotic transcription and its mechanism of action. However, the role of bent DNA in eukaryotic transcription remains unclear. Our recent study raises the possibility that bent DNA is implicated in the {"}functional packaging{"} of transcriptional regulatory regions into chromatin. In this article, I review recent progress in bent DNA research in eukaryotic transcription, and summarize the history of bent DNA research and several subjects relevant to this theme. Finally, I propose a hypothesis that bent DNA structures that mimic a negative supercoil, or have a right-handed superhelical writhe, organize local chromatin infrastructure to help the very first interaction between cis-acting DNA elements and activators that trigger transcription.",
author = "Takashi Ohyama",
year = "2001",
doi = "10.1002/bies.1100",
language = "English",
volume = "23",
pages = "708--715",
journal = "BioEssays",
issn = "0265-9247",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

TY - JOUR

T1 - Intrinsic DNA bends

T2 - An organizer of local chromatin structure for transcription

AU - Ohyama, Takashi

PY - 2001

Y1 - 2001

N2 - DNA with a curved trajectory of its helix axis is called bent DNA, or curved DNA. Interestingly, biologically important DNA regions often contain this structure, irrespective of the origin of DNA. In the last decade, considerable progress has been made in clarifying one role of bent DNA in prokaryotic transcription and its mechanism of action. However, the role of bent DNA in eukaryotic transcription remains unclear. Our recent study raises the possibility that bent DNA is implicated in the "functional packaging" of transcriptional regulatory regions into chromatin. In this article, I review recent progress in bent DNA research in eukaryotic transcription, and summarize the history of bent DNA research and several subjects relevant to this theme. Finally, I propose a hypothesis that bent DNA structures that mimic a negative supercoil, or have a right-handed superhelical writhe, organize local chromatin infrastructure to help the very first interaction between cis-acting DNA elements and activators that trigger transcription.

AB - DNA with a curved trajectory of its helix axis is called bent DNA, or curved DNA. Interestingly, biologically important DNA regions often contain this structure, irrespective of the origin of DNA. In the last decade, considerable progress has been made in clarifying one role of bent DNA in prokaryotic transcription and its mechanism of action. However, the role of bent DNA in eukaryotic transcription remains unclear. Our recent study raises the possibility that bent DNA is implicated in the "functional packaging" of transcriptional regulatory regions into chromatin. In this article, I review recent progress in bent DNA research in eukaryotic transcription, and summarize the history of bent DNA research and several subjects relevant to this theme. Finally, I propose a hypothesis that bent DNA structures that mimic a negative supercoil, or have a right-handed superhelical writhe, organize local chromatin infrastructure to help the very first interaction between cis-acting DNA elements and activators that trigger transcription.

UR - http://www.scopus.com/inward/record.url?scp=0034869839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034869839&partnerID=8YFLogxK

U2 - 10.1002/bies.1100

DO - 10.1002/bies.1100

M3 - Article

C2 - 11494319

AN - SCOPUS:0034869839

VL - 23

SP - 708

EP - 715

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 8

ER -