Inverse Association between Height-Increasing Alleles and Extreme Longevity in Japanese Women

Kumpei Tanisawa, Nobuyoshi Hirose, Yasumichi Arai, Hiroshi Shimokata, Yoshiji Yamada, Hisashi Kawai, Motonaga Kojima, Shuichi Obuchi, Hirohiko Hirano, Hiroyuki Suzuki, Yoshinori Fujiwara, Yu Taniguchi, Shoji Shinkai, Kazushige Ihara, Maki Sugaya, Mitsuru Higuchi, Tomio Arai, Seijiro Mori, Motoji Sawabe, Noriko SatoMasaaki Muramatsu, Masashi Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Growth hormone (GH)/insulin-like growth factor-1 (IGF-1)/insulin signaling is one of the most plausible biological pathways regulating aging and longevity. Previous studies have demonstrated that several single nucleotide polymorphisms (SNPs) in the GH/IGF-1/insulin signaling-associated genes influence both longevity and adult height, suggesting the possibility of a shared genetic architecture between longevity and height. We therefore examined the relationship between 30 height-associated SNPs and extreme longevity in a Japanese population consisting of 428 centenarians and 4,026 younger controls. We confirmed that height-increasing genetic scores (HGSs) constructed based on 30 SNPs were significantly associated with height in the controls (p = 6.951023). HGS was significantly and inversely associated with extreme longevity in women (p = .011), but not in men, although no SNPs were significantly associated with extreme longevity after Bonferroni correction. The odds ratio for extreme longevity in the lowest HGS group (=27) and the second lowest HGS group (2830) relative to the highest HGS group (=37) was 1.71 (p = .056) and 1.69 (p = .034), respectively, for women. In conclusion, the present study demonstrated an inverse association between height-increasing alleles with extreme longevity in Japanese women, providing novel insight into the genetic architecture of longevity and aging.

Original languageEnglish
Pages (from-to)588-595
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume73
Issue number5
DOIs
Publication statusPublished - 2018 Apr 17

Keywords

  • Centenarian
  • Human genetics
  • IGF-1
  • Longevity

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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    Tanisawa, K., Hirose, N., Arai, Y., Shimokata, H., Yamada, Y., Kawai, H., Kojima, M., Obuchi, S., Hirano, H., Suzuki, H., Fujiwara, Y., Taniguchi, Y., Shinkai, S., Ihara, K., Sugaya, M., Higuchi, M., Arai, T., Mori, S., Sawabe, M., ... Tanaka, M. (2018). Inverse Association between Height-Increasing Alleles and Extreme Longevity in Japanese Women. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 73(5), 588-595. https://doi.org/10.1093/gerona/glx155