Investigation of a hydrodynamic performance of a ventricular assist device after its long-term use in clinical application

Yuma Kokuzawa, Tomohiro Shima, Masateru Furusato, Kazuhiko Ito, Takashi Tanaka, Toshihiro Igarashi, Tomohiro Nishinaka, Kiyotaka Iwasaki, Mitsuo Umezu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A long-term durability of a ventricular assist device (VAD) is required due to a shortage of donor hearts for cardiac transplantation, but there is no analyzed pump data after long-term use. This study aimed to perform a comparative study between new VAD and VADs after long-term use. The hydrodynamic performance of the used Toyobo VADs (mean period of 5 months with the maximum of 12 months) was evaluated in a mock circulatory system, where a new VAD was used as a control. Although a remarkable difference was not observed in terms of mean flow rate, flow and pressure waveforms varied significantly. Then, the pressure-volume relationship of each pump was measured. It was found that the capacity of long-term VADs was reduced. Although a further study is required, these results suggested that a long-term use of VAD may cause a change in mechanical properties of polymer materials.

Original languageEnglish
Title of host publicationLife System Modeling and Simulation - International Conference, LSMS 2007, Proceedings
Pages429-435
Number of pages7
Publication statusPublished - 2007 Dec 1
Event2007 International Conference on Life System Modeling and Simulation, LSMS 2007 - Shanghai, China
Duration: 2007 Sep 142007 Sep 17

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4689 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference2007 International Conference on Life System Modeling and Simulation, LSMS 2007
CountryChina
CityShanghai
Period07/9/1407/9/17

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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