Investigation of a hydrodynamic performance of a ventricular assist device after its long-term use in clinical application

Yuma Kokuzawa, Tomohiro Shima, Masateru Furusato, Kazuhiko Ito, Takashi Tanaka, Toshihiro Igarashi, Tomohiro Nishinaka, Kiyotaka Iwasaki, Mitsuo Umezu

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    A long-term durability of a ventricular assist device (VAD) is required due to a shortage of donor hearts for cardiac transplantation, but there is no analyzed pump data after long-term use. This study aimed to perform a comparative study between new VAD and VADs after long-term use. The hydrodynamic performance of the used Toyobo VADs (mean period of 5 months with the maximum of 12 months) was evaluated in a mock circulatory system, where a new VAD was used as a control. Although a remarkable difference was not observed in terms of mean flow rate, flow and pressure waveforms varied significantly. Then, the pressure-volume relationship of each pump was measured. It was found that the capacity of long-term VADs was reduced. Although a further study is required, these results suggested that a long-term use of VAD may cause a change in mechanical properties of polymer materials.

    Original languageEnglish
    Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Pages429-435
    Number of pages7
    Volume4689 LNBI
    Publication statusPublished - 2007
    Event2007 International Conference on Life System Modeling and Simulation, LSMS 2007 - Shanghai
    Duration: 2007 Sep 142007 Sep 17

    Publication series

    NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Volume4689 LNBI
    ISSN (Print)03029743
    ISSN (Electronic)16113349

    Other

    Other2007 International Conference on Life System Modeling and Simulation, LSMS 2007
    CityShanghai
    Period07/9/1407/9/17

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    ASJC Scopus subject areas

    • Computer Science(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Theoretical Computer Science

    Cite this

    Kokuzawa, Y., Shima, T., Furusato, M., Ito, K., Tanaka, T., Igarashi, T., Nishinaka, T., Iwasaki, K., & Umezu, M. (2007). Investigation of a hydrodynamic performance of a ventricular assist device after its long-term use in clinical application. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4689 LNBI, pp. 429-435). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4689 LNBI).