Disulfide bonds of peptides were effectively established between S-protected cysteine residues as well as free cysteine residues by the action of dimethylsulfoxide in trifluoroacetic acid. Oxytocin and a-human calcitonin gene-related peptide were synthesized using this oxidation system. The feasibility of this method for the formation of two disulfide bridges of apamin was also examined.
- Keywords cystine-containing peptide
- calcitonin gene-related peptide
- disulfide bond-formation
ASJC Scopus subject areas
- Drug Discovery