Involvement of μ1-opioid receptor on oxycodone-induced antinociception in diabetic mice

Chihiro Nozaki, Junzo Kamei

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The effect of naloxonazine, a selective μ1-opioid receptor antagonist, on oxycodone-induced antinociception was examined in streptozotocin-induced diabetic mice. Oxycodone (5 mg/kg, s.c.) induced significant antinociception in both non-diabetic and diabetic mice. This antinociceptive effect of oxycodone was completely antagonized by pretreatment with naloxonazine (35 mg/kg, s.c.) in both non-diabetic and diabetic mice. The selective κ-opioid receptor antagonist nor-binaltorphimine (20 mg/kg, s.c.) also antagonized oxycodone-induced antinociception in diabetic mice, but only had a partial effect in non-diabetic mice. These results suggest that although primarily interacts with μ1-opioid receptor, κ-opioid receptors are also strongly involved in oxycodone-induced antinociception.

Original languageEnglish
Pages (from-to)160-162
Number of pages3
JournalEuropean Journal of Pharmacology
Volume560
Issue number2-3
DOIs
Publication statusPublished - 2007 Apr 10
Externally publishedYes

Keywords

  • Diabetes
  • Hyperalgesia
  • Oxycodone
  • κ-Opioid receptor
  • μ-Opioid receptor

ASJC Scopus subject areas

  • Pharmacology

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