Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus

Takahiro Moriya, Shiro Yamanouchi, Tatsuto Fukushima, Takao Shimazoe, Shigenobu Shibata, Shigenori Watanabe

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    We examined the role of serotonin 1A (5-HT(1A)) receptors in the inhibitory effects of methamphetamine (MA) on photic entrainment to the circadian pacemaker in the suprachiasmatic nucleus (SCN) of rodents. MA inhibited optic nerve stimulation-evoked field potential in the SCN, light-induced Fos expression in the SCN and light-induced phase shift of hamster wheel-running rhythm. NAN-190, a 5-HT(1A) receptor antagonist, eliminated the inhibitory effects of MA. NAN-190 has also been reported to antagonize α1 adrenergic receptors. However, prazosin, which selectively antagonizes α1 adrenergic receptors, did not affect the inhibitory action of MA on light-induced Fos expression. In addition, parachloroamphetamine, which is known to be a 5-HT releaser, dose-dependently inhibited light-induced phase shift of wheel-running rhythm. These findings suggest that elevation of endogenous 5-HT levels by MA inhibits the photic entraining responses of the circadian pacemaker in the SCN via 5-HT(1A) receptor stimulation of the 5-HT released by MA.

    Original languageEnglish
    Pages (from-to)261-267
    Number of pages7
    JournalBrain Research
    Volume740
    Issue number1-2
    DOIs
    Publication statusPublished - 1996 Nov 18

    Fingerprint

    Suprachiasmatic Nucleus
    Receptor, Serotonin, 5-HT1A
    Methamphetamine
    Rodentia
    Serotonin
    Light
    Running
    Adrenergic Receptors
    p-Chloroamphetamine
    Prazosin
    Optic Nerve
    Evoked Potentials
    Cricetinae

    Keywords

    • 5-HT(1A) receptor
    • circadian rhythm
    • methamphetamine
    • NAN-190
    • serotonin
    • suprachiasmatic nucleus

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Clinical Neurology
    • Developmental Biology
    • Molecular Biology

    Cite this

    Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus. / Moriya, Takahiro; Yamanouchi, Shiro; Fukushima, Tatsuto; Shimazoe, Takao; Shibata, Shigenobu; Watanabe, Shigenori.

    In: Brain Research, Vol. 740, No. 1-2, 18.11.1996, p. 261-267.

    Research output: Contribution to journalArticle

    Moriya, Takahiro ; Yamanouchi, Shiro ; Fukushima, Tatsuto ; Shimazoe, Takao ; Shibata, Shigenobu ; Watanabe, Shigenori. / Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus. In: Brain Research. 1996 ; Vol. 740, No. 1-2. pp. 261-267.
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