Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus

Takahiro Moriya; Shiro Yamanouchi; Tatsuto Fukushima; Takao Shimazoe; Shigenobu Shibata; Shigenori Watanabe

doi:10.1016/S0006-8993(96)00860-8

Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus

Takahiro Moriya, Shiro Yamanouchi, Tatsuto Fukushima, Takao Shimazoe, Shigenobu Shibata, Shigenori Watanabe

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We examined the role of serotonin 1A (5-HT(1A)) receptors in the inhibitory effects of methamphetamine (MA) on photic entrainment to the circadian pacemaker in the suprachiasmatic nucleus (SCN) of rodents. MA inhibited optic nerve stimulation-evoked field potential in the SCN, light-induced Fos expression in the SCN and light-induced phase shift of hamster wheel-running rhythm. NAN-190, a 5-HT(1A) receptor antagonist, eliminated the inhibitory effects of MA. NAN-190 has also been reported to antagonize α₁ adrenergic receptors. However, prazosin, which selectively antagonizes α₁ adrenergic receptors, did not affect the inhibitory action of MA on light-induced Fos expression. In addition, parachloroamphetamine, which is known to be a 5-HT releaser, dose-dependently inhibited light-induced phase shift of wheel-running rhythm. These findings suggest that elevation of endogenous 5-HT levels by MA inhibits the photic entraining responses of the circadian pacemaker in the SCN via 5-HT(1A) receptor stimulation of the 5-HT released by MA.

Original language	English
Pages (from-to)	261-267
Number of pages	7
Journal	Brain Research
Volume	740
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(96)00860-8
Publication status	Published - 1996 Nov 18

Keywords

5-HT(1A) receptor
NAN-190
circadian rhythm
methamphetamine
serotonin
suprachiasmatic nucleus

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/S0006-8993(96)00860-8

Fingerprint Dive into the research topics of 'Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus'. Together they form a unique fingerprint.

Cite this

Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus. / Moriya, Takahiro; Yamanouchi, Shiro; Fukushima, Tatsuto; Shimazoe, Takao; Shibata, Shigenobu; Watanabe, Shigenori.

In: Brain Research, Vol. 740, No. 1-2, 18.11.1996, p. 261-267.

Research output: Contribution to journal › Article › peer-review

@article{ad3953868a50409e985cf8a78040dbb4,

title = "Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus",

abstract = "We examined the role of serotonin 1A (5-HT(1A)) receptors in the inhibitory effects of methamphetamine (MA) on photic entrainment to the circadian pacemaker in the suprachiasmatic nucleus (SCN) of rodents. MA inhibited optic nerve stimulation-evoked field potential in the SCN, light-induced Fos expression in the SCN and light-induced phase shift of hamster wheel-running rhythm. NAN-190, a 5-HT(1A) receptor antagonist, eliminated the inhibitory effects of MA. NAN-190 has also been reported to antagonize α1 adrenergic receptors. However, prazosin, which selectively antagonizes α1 adrenergic receptors, did not affect the inhibitory action of MA on light-induced Fos expression. In addition, parachloroamphetamine, which is known to be a 5-HT releaser, dose-dependently inhibited light-induced phase shift of wheel-running rhythm. These findings suggest that elevation of endogenous 5-HT levels by MA inhibits the photic entraining responses of the circadian pacemaker in the SCN via 5-HT(1A) receptor stimulation of the 5-HT released by MA.",

keywords = "5-HT(1A) receptor, NAN-190, circadian rhythm, methamphetamine, serotonin, suprachiasmatic nucleus",

author = "Takahiro Moriya and Shiro Yamanouchi and Tatsuto Fukushima and Takao Shimazoe and Shigenobu Shibata and Shigenori Watanabe",

year = "1996",

month = nov,

day = "18",

doi = "10.1016/S0006-8993(96)00860-8",

language = "English",

volume = "740",

pages = "261--267",

journal = "Brain Research",

issn = "0006-8993",

number = "1-2",

}

TY - JOUR

T1 - Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus

AU - Moriya, Takahiro

AU - Yamanouchi, Shiro

AU - Fukushima, Tatsuto

AU - Shimazoe, Takao

AU - Shibata, Shigenobu

AU - Watanabe, Shigenori

PY - 1996/11/18

Y1 - 1996/11/18

N2 - We examined the role of serotonin 1A (5-HT(1A)) receptors in the inhibitory effects of methamphetamine (MA) on photic entrainment to the circadian pacemaker in the suprachiasmatic nucleus (SCN) of rodents. MA inhibited optic nerve stimulation-evoked field potential in the SCN, light-induced Fos expression in the SCN and light-induced phase shift of hamster wheel-running rhythm. NAN-190, a 5-HT(1A) receptor antagonist, eliminated the inhibitory effects of MA. NAN-190 has also been reported to antagonize α1 adrenergic receptors. However, prazosin, which selectively antagonizes α1 adrenergic receptors, did not affect the inhibitory action of MA on light-induced Fos expression. In addition, parachloroamphetamine, which is known to be a 5-HT releaser, dose-dependently inhibited light-induced phase shift of wheel-running rhythm. These findings suggest that elevation of endogenous 5-HT levels by MA inhibits the photic entraining responses of the circadian pacemaker in the SCN via 5-HT(1A) receptor stimulation of the 5-HT released by MA.

AB - We examined the role of serotonin 1A (5-HT(1A)) receptors in the inhibitory effects of methamphetamine (MA) on photic entrainment to the circadian pacemaker in the suprachiasmatic nucleus (SCN) of rodents. MA inhibited optic nerve stimulation-evoked field potential in the SCN, light-induced Fos expression in the SCN and light-induced phase shift of hamster wheel-running rhythm. NAN-190, a 5-HT(1A) receptor antagonist, eliminated the inhibitory effects of MA. NAN-190 has also been reported to antagonize α1 adrenergic receptors. However, prazosin, which selectively antagonizes α1 adrenergic receptors, did not affect the inhibitory action of MA on light-induced Fos expression. In addition, parachloroamphetamine, which is known to be a 5-HT releaser, dose-dependently inhibited light-induced phase shift of wheel-running rhythm. These findings suggest that elevation of endogenous 5-HT levels by MA inhibits the photic entraining responses of the circadian pacemaker in the SCN via 5-HT(1A) receptor stimulation of the 5-HT released by MA.

KW - 5-HT(1A) receptor

KW - NAN-190

KW - circadian rhythm

KW - methamphetamine

KW - serotonin

KW - suprachiasmatic nucleus

UR - http://www.scopus.com/inward/record.url?scp=0030592587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030592587&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(96)00860-8

DO - 10.1016/S0006-8993(96)00860-8

M3 - Article

C2 - 8973823

AN - SCOPUS:0030592587

VL - 740

SP - 261

EP - 267

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -

Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this