Abstract
We examined the role of serotonin 1A (5-HT(1A)) receptors in the inhibitory effects of methamphetamine (MA) on photic entrainment to the circadian pacemaker in the suprachiasmatic nucleus (SCN) of rodents. MA inhibited optic nerve stimulation-evoked field potential in the SCN, light-induced Fos expression in the SCN and light-induced phase shift of hamster wheel-running rhythm. NAN-190, a 5-HT(1A) receptor antagonist, eliminated the inhibitory effects of MA. NAN-190 has also been reported to antagonize α1 adrenergic receptors. However, prazosin, which selectively antagonizes α1 adrenergic receptors, did not affect the inhibitory action of MA on light-induced Fos expression. In addition, parachloroamphetamine, which is known to be a 5-HT releaser, dose-dependently inhibited light-induced phase shift of wheel-running rhythm. These findings suggest that elevation of endogenous 5-HT levels by MA inhibits the photic entraining responses of the circadian pacemaker in the SCN via 5-HT(1A) receptor stimulation of the 5-HT released by MA.
| Original language | English |
|---|---|
| Pages (from-to) | 261-267 |
| Number of pages | 7 |
| Journal | Brain Research |
| Volume | 740 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 1996 Nov 18 |
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Keywords
- 5-HT(1A) receptor
- circadian rhythm
- methamphetamine
- NAN-190
- serotonin
- suprachiasmatic nucleus
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
- Developmental Biology
- Molecular Biology
Cite this
Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus. / Moriya, Takahiro; Yamanouchi, Shiro; Fukushima, Tatsuto; Shimazoe, Takao; Shibata, Shigenobu; Watanabe, Shigenori.
In: Brain Research, Vol. 740, No. 1-2, 18.11.1996, p. 261-267.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus
AU - Moriya, Takahiro
AU - Yamanouchi, Shiro
AU - Fukushima, Tatsuto
AU - Shimazoe, Takao
AU - Shibata, Shigenobu
AU - Watanabe, Shigenori
PY - 1996/11/18
Y1 - 1996/11/18
N2 - We examined the role of serotonin 1A (5-HT(1A)) receptors in the inhibitory effects of methamphetamine (MA) on photic entrainment to the circadian pacemaker in the suprachiasmatic nucleus (SCN) of rodents. MA inhibited optic nerve stimulation-evoked field potential in the SCN, light-induced Fos expression in the SCN and light-induced phase shift of hamster wheel-running rhythm. NAN-190, a 5-HT(1A) receptor antagonist, eliminated the inhibitory effects of MA. NAN-190 has also been reported to antagonize α1 adrenergic receptors. However, prazosin, which selectively antagonizes α1 adrenergic receptors, did not affect the inhibitory action of MA on light-induced Fos expression. In addition, parachloroamphetamine, which is known to be a 5-HT releaser, dose-dependently inhibited light-induced phase shift of wheel-running rhythm. These findings suggest that elevation of endogenous 5-HT levels by MA inhibits the photic entraining responses of the circadian pacemaker in the SCN via 5-HT(1A) receptor stimulation of the 5-HT released by MA.
AB - We examined the role of serotonin 1A (5-HT(1A)) receptors in the inhibitory effects of methamphetamine (MA) on photic entrainment to the circadian pacemaker in the suprachiasmatic nucleus (SCN) of rodents. MA inhibited optic nerve stimulation-evoked field potential in the SCN, light-induced Fos expression in the SCN and light-induced phase shift of hamster wheel-running rhythm. NAN-190, a 5-HT(1A) receptor antagonist, eliminated the inhibitory effects of MA. NAN-190 has also been reported to antagonize α1 adrenergic receptors. However, prazosin, which selectively antagonizes α1 adrenergic receptors, did not affect the inhibitory action of MA on light-induced Fos expression. In addition, parachloroamphetamine, which is known to be a 5-HT releaser, dose-dependently inhibited light-induced phase shift of wheel-running rhythm. These findings suggest that elevation of endogenous 5-HT levels by MA inhibits the photic entraining responses of the circadian pacemaker in the SCN via 5-HT(1A) receptor stimulation of the 5-HT released by MA.
KW - 5-HT(1A) receptor
KW - circadian rhythm
KW - methamphetamine
KW - NAN-190
KW - serotonin
KW - suprachiasmatic nucleus
UR - http://www.scopus.com/inward/record.url?scp=0030592587&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030592587&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(96)00860-8
DO - 10.1016/S0006-8993(96)00860-8
M3 - Article
C2 - 8973823
AN - SCOPUS:0030592587
VL - 740
SP - 261
EP - 267
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -