Involvement of D1 dopamine receptor mechanism in ischemia-induced impairment of CA1 presynaptic fiber spikes in rat hippocampal slices

Yasaharu Yamamoto, Takeshi Tanaka, Shigenobu Shibata, Shigenori Watanabe

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effect of dopamine (DA) receptor agonists and antagonists on hypoxia/hypoglycemia (ischemia)-induced decrease in CA1 presynaptic fiber spikes elicited by the stimulation of Schaffer collateral were investigated using hippocampal slices. Treatment with D1 dopamine receptor antagonist, SCH23390 produced a concentration-dependent attenuation of the ischemia-induced decrease of presynaptic potentials. The magnitude of recovery of the CA1 presynaptic potential in SCH23390-treated slices at 10 and 100 μM was 28 and 54%, respectively. Whereas, treatment with D1 dopamine receptor agonist, SKF38393 exacerbated the ischemia-induced decrease in the CA1 presynaptic potential. The decrease of CA1 presynaptic potential by ischemia was affected by neither D2 dopamine receptor agonist, bromocriptin and quinpirole nor D2 dopamine receptor antagonist, sulpiride. The neuroprotective effect of SCH23390 was completely blocked by cotreatment with SKF38393. The present results demonstrated that the blockade of D1 dopamine receptor function played a neuroprotective role in ischemic damage, suggesting a facilitatory role of D1 dopamine receptor-operated function in ischemia-induced neuronal deficits.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalBrain Research
Volume665
Issue number1
DOIs
Publication statusPublished - 1994 Nov 28
Externally publishedYes

Fingerprint

Dopamine D1 Receptors
Ischemia
Dopamine Agonists
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Dopamine Antagonists
Quinpirole
Sulpiride
Bromocriptine
Neuroprotective Agents
Hypoglycemia
Hippocampus
SCH 23390

Keywords

  • CA1
  • Dopamine
  • Hippocampus
  • Ischemia
  • Neuroprotection
  • Presynaptic fiber spike

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Involvement of D1 dopamine receptor mechanism in ischemia-induced impairment of CA1 presynaptic fiber spikes in rat hippocampal slices. / Yamamoto, Yasaharu; Tanaka, Takeshi; Shibata, Shigenobu; Watanabe, Shigenori.

In: Brain Research, Vol. 665, No. 1, 28.11.1994, p. 151-154.

Research output: Contribution to journalArticle

@article{9946412b9ccb40409771dfd70532f8c1,
title = "Involvement of D1 dopamine receptor mechanism in ischemia-induced impairment of CA1 presynaptic fiber spikes in rat hippocampal slices",
abstract = "The effect of dopamine (DA) receptor agonists and antagonists on hypoxia/hypoglycemia (ischemia)-induced decrease in CA1 presynaptic fiber spikes elicited by the stimulation of Schaffer collateral were investigated using hippocampal slices. Treatment with D1 dopamine receptor antagonist, SCH23390 produced a concentration-dependent attenuation of the ischemia-induced decrease of presynaptic potentials. The magnitude of recovery of the CA1 presynaptic potential in SCH23390-treated slices at 10 and 100 μM was 28 and 54{\%}, respectively. Whereas, treatment with D1 dopamine receptor agonist, SKF38393 exacerbated the ischemia-induced decrease in the CA1 presynaptic potential. The decrease of CA1 presynaptic potential by ischemia was affected by neither D2 dopamine receptor agonist, bromocriptin and quinpirole nor D2 dopamine receptor antagonist, sulpiride. The neuroprotective effect of SCH23390 was completely blocked by cotreatment with SKF38393. The present results demonstrated that the blockade of D1 dopamine receptor function played a neuroprotective role in ischemic damage, suggesting a facilitatory role of D1 dopamine receptor-operated function in ischemia-induced neuronal deficits.",
keywords = "CA1, Dopamine, Hippocampus, Ischemia, Neuroprotection, Presynaptic fiber spike",
author = "Yasaharu Yamamoto and Takeshi Tanaka and Shigenobu Shibata and Shigenori Watanabe",
year = "1994",
month = "11",
day = "28",
doi = "10.1016/0006-8993(94)91166-5",
language = "English",
volume = "665",
pages = "151--154",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Involvement of D1 dopamine receptor mechanism in ischemia-induced impairment of CA1 presynaptic fiber spikes in rat hippocampal slices

AU - Yamamoto, Yasaharu

AU - Tanaka, Takeshi

AU - Shibata, Shigenobu

AU - Watanabe, Shigenori

PY - 1994/11/28

Y1 - 1994/11/28

N2 - The effect of dopamine (DA) receptor agonists and antagonists on hypoxia/hypoglycemia (ischemia)-induced decrease in CA1 presynaptic fiber spikes elicited by the stimulation of Schaffer collateral were investigated using hippocampal slices. Treatment with D1 dopamine receptor antagonist, SCH23390 produced a concentration-dependent attenuation of the ischemia-induced decrease of presynaptic potentials. The magnitude of recovery of the CA1 presynaptic potential in SCH23390-treated slices at 10 and 100 μM was 28 and 54%, respectively. Whereas, treatment with D1 dopamine receptor agonist, SKF38393 exacerbated the ischemia-induced decrease in the CA1 presynaptic potential. The decrease of CA1 presynaptic potential by ischemia was affected by neither D2 dopamine receptor agonist, bromocriptin and quinpirole nor D2 dopamine receptor antagonist, sulpiride. The neuroprotective effect of SCH23390 was completely blocked by cotreatment with SKF38393. The present results demonstrated that the blockade of D1 dopamine receptor function played a neuroprotective role in ischemic damage, suggesting a facilitatory role of D1 dopamine receptor-operated function in ischemia-induced neuronal deficits.

AB - The effect of dopamine (DA) receptor agonists and antagonists on hypoxia/hypoglycemia (ischemia)-induced decrease in CA1 presynaptic fiber spikes elicited by the stimulation of Schaffer collateral were investigated using hippocampal slices. Treatment with D1 dopamine receptor antagonist, SCH23390 produced a concentration-dependent attenuation of the ischemia-induced decrease of presynaptic potentials. The magnitude of recovery of the CA1 presynaptic potential in SCH23390-treated slices at 10 and 100 μM was 28 and 54%, respectively. Whereas, treatment with D1 dopamine receptor agonist, SKF38393 exacerbated the ischemia-induced decrease in the CA1 presynaptic potential. The decrease of CA1 presynaptic potential by ischemia was affected by neither D2 dopamine receptor agonist, bromocriptin and quinpirole nor D2 dopamine receptor antagonist, sulpiride. The neuroprotective effect of SCH23390 was completely blocked by cotreatment with SKF38393. The present results demonstrated that the blockade of D1 dopamine receptor function played a neuroprotective role in ischemic damage, suggesting a facilitatory role of D1 dopamine receptor-operated function in ischemia-induced neuronal deficits.

KW - CA1

KW - Dopamine

KW - Hippocampus

KW - Ischemia

KW - Neuroprotection

KW - Presynaptic fiber spike

UR - http://www.scopus.com/inward/record.url?scp=0028173620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028173620&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(94)91166-5

DO - 10.1016/0006-8993(94)91166-5

M3 - Article

C2 - 7882009

AN - SCOPUS:0028173620

VL - 665

SP - 151

EP - 154

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -