Involvement of ryanodine receptor type 3 in dopamine release from the striatum: Evidence from mutant mice lacking this receptor

Keiko Wan, Takahiro Moriya, Masashi Akiyama, Hiroshi Takeshima, Shigenobu Shibata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Although it is known that ryanodine receptor type 3 is expressed in the striatum, the function of this receptor has not been elucidated. Therefore, we examined whether caffeine- and ryanodine-induced dopamine release in striatal slices is affected in mice lacking ryanodine receptor type 3. Pretreatment with thapsigargin, an inhibitor of the Ca2+ ATPase pump of the endoplasmic reticulum, abolished caffeine- or ryanodine-induced dopamine release in slices from normal mice. Dopamine concentration in the striatum and KCl-induced dopamine release were unaffected by a ryanodine receptor type 3 deficiency. Ryanodine-induced dopamine release was significantly attenuated in mice lacking ryanodine receptor type 3, whereas caffeine-induced dopamine release was partially attenuated. Caffeine produced a similar hypermotor activity in both wild and homozygous mice. The present results suggest the involvement of ryanodine receptor type 3 in dopamine release from the striatum.

Original languageEnglish
Pages (from-to)588-592
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume266
Issue number2
DOIs
Publication statusPublished - 1999 Dec 20

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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