Involvement of ryanodine receptor type 3 in dopamine release from the striatum: Evidence from mutant mice lacking this receptor

Keiko Wan, Takahiro Moriya, Masashi Akiyama, Hiroshi Takeshima, Shigenobu Shibata

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    6 Citations (Scopus)

    Abstract

    Although it is known that ryanodine receptor type 3 is expressed in the striatum, the function of this receptor has not been elucidated. Therefore, we examined whether caffeine- and ryanodine-induced dopamine release in striatal slices is affected in mice lacking ryanodine receptor type 3. Pretreatment with thapsigargin, an inhibitor of the Ca2+ ATPase pump of the endoplasmic reticulum, abolished caffeine- or ryanodine-induced dopamine release in slices from normal mice. Dopamine concentration in the striatum and KCl-induced dopamine release were unaffected by a ryanodine receptor type 3 deficiency. Ryanodine-induced dopamine release was significantly attenuated in mice lacking ryanodine receptor type 3, whereas caffeine-induced dopamine release was partially attenuated. Caffeine produced a similar hypermotor activity in both wild and homozygous mice. The present results suggest the involvement of ryanodine receptor type 3 in dopamine release from the striatum.

    Original languageEnglish
    Pages (from-to)588-592
    Number of pages5
    JournalBiochemical and Biophysical Research Communications
    Volume266
    Issue number2
    DOIs
    Publication statusPublished - 1999 Dec 20

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    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

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