Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease

Yoshitaka Kondo, Akihito Ishigami*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Senescence marker protein-30 (SMP30) was found to decrease in the liver, kidneys and lungs of mice during aging. SMP30 is a pleiotropic protein that acts to protect cells from apoptosis by enhancing plasma membrane Ca2+-pump activity and is bona fide gluconolactonase (EC 3.1.1.17) that participates in the penultimate step of the vitaminC biosynthetic pathway. For the past several years, we have obtained strong evidence showing the close relationship between SMP30, glucose metabolism disorder and non-alchoholic fatty liver disease in experiments with SMP30 knockout mice. Emerging proof links the following abnormalities: (i) the reduction of SMP30 by aging and/or excessive dietary fat or genetic deficiency causes a loss of Ca2+ pumping activity, which impairs acute insulin release in pancreatic β-cells, initiates inflammatory responses with oxidative stress and endoplasmic reticulum stress in non-alchoholic steatohepatitis, exacerbates renal tubule damage, and introduces tubulointerstitial inflammation and fibrosis in diabetic nephropathy; (ii) vitaminC insufficiency also impairs acute insulin secretion in pancreatic β-cells by a mechanism distinct from that of the SMP30 deficiency; and (iii) the increased oxidative stress by concomitant deficiencies of SMP30, superoxide dismutase 1 and vitaminC similarly causes hepatic steatosis. Here, we review recent advances in our understanding of SMP30 in glucose metabolism disorder and non-alchoholic fatty liver disease.

Original languageEnglish
Pages (from-to)4-16
Number of pages13
JournalGeriatrics and Gerontology International
Volume16
DOIs
Publication statusPublished - 2016 Mar 1
Externally publishedYes

Keywords

  • Aging
  • Diabetes mellitus
  • Non-alchoholic fatty liver disease
  • Senescence marker protein-30
  • VitaminC

ASJC Scopus subject areas

  • Health(social science)
  • Gerontology
  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease'. Together they form a unique fingerprint.

Cite this