Abstract
We previously found that splenectomy caused a 1-day delay in ovulation in cycling rats. In the present study, the role of the spleen or splenocytes in corpus luteum function was investigated by comparing long-term splenectomized (SPX) rats with intact controls. When the rats were cervically stimulated on the day of proestrus, both SPX and control rats showed prolonged diestrus for 16 days associated with an increase in serum progesterone (P). However, in SPX rats, 20α-dihydroprogesterone (20α-OHP) concentrations were double those of controls throughout the period of pseudopregnancy. The concentration of total progestin (P plus 20α-OHP) was also higher in SPX rats. All of these phenomena were normalized by injecting the animals with splenocytes. Taken together with our previous findings, these results indicate that splenocytes are involved in the control of ovarian function.
| Original language | English |
|---|---|
| Pages (from-to) | 891-898 |
| Number of pages | 8 |
| Journal | Endocrinologia Japonica |
| Volume | 35 |
| Issue number | 6 |
| Publication status | Published - 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
Cite this
Involvement of splenocytes in the control of corpus luteum function in the rat. / Saito, S.; Matsuyama, S.; Shiota, K.; Takahashi, M.
In: Endocrinologia Japonica, Vol. 35, No. 6, 1988, p. 891-898.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Involvement of splenocytes in the control of corpus luteum function in the rat
AU - Saito, S.
AU - Matsuyama, S.
AU - Shiota, K.
AU - Takahashi, M.
PY - 1988
Y1 - 1988
N2 - We previously found that splenectomy caused a 1-day delay in ovulation in cycling rats. In the present study, the role of the spleen or splenocytes in corpus luteum function was investigated by comparing long-term splenectomized (SPX) rats with intact controls. When the rats were cervically stimulated on the day of proestrus, both SPX and control rats showed prolonged diestrus for 16 days associated with an increase in serum progesterone (P). However, in SPX rats, 20α-dihydroprogesterone (20α-OHP) concentrations were double those of controls throughout the period of pseudopregnancy. The concentration of total progestin (P plus 20α-OHP) was also higher in SPX rats. All of these phenomena were normalized by injecting the animals with splenocytes. Taken together with our previous findings, these results indicate that splenocytes are involved in the control of ovarian function.
AB - We previously found that splenectomy caused a 1-day delay in ovulation in cycling rats. In the present study, the role of the spleen or splenocytes in corpus luteum function was investigated by comparing long-term splenectomized (SPX) rats with intact controls. When the rats were cervically stimulated on the day of proestrus, both SPX and control rats showed prolonged diestrus for 16 days associated with an increase in serum progesterone (P). However, in SPX rats, 20α-dihydroprogesterone (20α-OHP) concentrations were double those of controls throughout the period of pseudopregnancy. The concentration of total progestin (P plus 20α-OHP) was also higher in SPX rats. All of these phenomena were normalized by injecting the animals with splenocytes. Taken together with our previous findings, these results indicate that splenocytes are involved in the control of ovarian function.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024149109&partnerID=8YFLogxK
M3 - Article
C2 - 3250864
AN - SCOPUS:0024149109
VL - 35
SP - 891
EP - 898
JO - Endocrine Journal
JF - Endocrine Journal
SN - 0918-8959
IS - 6
ER -