Involvement of splenocytes in the control of corpus luteum function in the rat

S. Saito, S. Matsuyama, K. Shiota, M. Takahashi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We previously found that splenectomy caused a 1-day delay in ovulation in cycling rats. In the present study, the role of the spleen or splenocytes in corpus luteum function was investigated by comparing long-term splenectomized (SPX) rats with intact controls. When the rats were cervically stimulated on the day of proestrus, both SPX and control rats showed prolonged diestrus for 16 days associated with an increase in serum progesterone (P). However, in SPX rats, 20α-dihydroprogesterone (20α-OHP) concentrations were double those of controls throughout the period of pseudopregnancy. The concentration of total progestin (P plus 20α-OHP) was also higher in SPX rats. All of these phenomena were normalized by injecting the animals with splenocytes. Taken together with our previous findings, these results indicate that splenocytes are involved in the control of ovarian function.

Original languageEnglish
Pages (from-to)891-898
Number of pages8
JournalEndocrinologia Japonica
Volume35
Issue number6
Publication statusPublished - 1988
Externally publishedYes

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Corpus Luteum
20-alpha-Dihydroprogesterone
Pseudopregnancy
Diestrus
Proestrus
Splenectomy
Progestins
Ovulation
Progesterone
Spleen
Serum

ASJC Scopus subject areas

  • Endocrinology

Cite this

Saito, S., Matsuyama, S., Shiota, K., & Takahashi, M. (1988). Involvement of splenocytes in the control of corpus luteum function in the rat. Endocrinologia Japonica, 35(6), 891-898.

Involvement of splenocytes in the control of corpus luteum function in the rat. / Saito, S.; Matsuyama, S.; Shiota, K.; Takahashi, M.

In: Endocrinologia Japonica, Vol. 35, No. 6, 1988, p. 891-898.

Research output: Contribution to journalArticle

Saito, S, Matsuyama, S, Shiota, K & Takahashi, M 1988, 'Involvement of splenocytes in the control of corpus luteum function in the rat', Endocrinologia Japonica, vol. 35, no. 6, pp. 891-898.
Saito S, Matsuyama S, Shiota K, Takahashi M. Involvement of splenocytes in the control of corpus luteum function in the rat. Endocrinologia Japonica. 1988;35(6):891-898.
Saito, S. ; Matsuyama, S. ; Shiota, K. ; Takahashi, M. / Involvement of splenocytes in the control of corpus luteum function in the rat. In: Endocrinologia Japonica. 1988 ; Vol. 35, No. 6. pp. 891-898.
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