Involvement of the raphé pallidus in the suppressive effect of preoptic warming on non-shivering thermogenesis in rats

Aki Taniguchi; Xiao Ming Chen; Kei Nagashima; Mutsumi Tanaka; Kazuyuki Kanosue

doi:10.1016/S0006-8993(02)04203-8

Involvement of the raphé pallidus in the suppressive effect of preoptic warming on non-shivering thermogenesis in rats

Aki Taniguchi, Xiao Ming Chen, Kei Nagashima, Mutsumi Tanaka, Kazuyuki Kanosue^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Thermogenesis in the brown adipose tissue (BAT) is activated by the stimulation of the ventromedial hypothalamic nucleus (VMH). Local warming of the preoptic area (PO) suppresses this response. Injection of the GABA_A receptor antagonist bicuculline into the caudal periaqueductal gray (cPAG), where excitatory neurons for BAT thermogenesis are located, did not influence the suppressive effect of PO warming. On the other hand, after bicuculline injection into the raphé pallidus, where excitatory neurons for BAT thermogenesis are also located, VMH stimulation produced BAT thermogenesis even during PO warming. The present results suggest that the inhibitory signal from the PO reaches the raphé pallidus and not the cPAG for the control of BAT thermogenesis.

Original language	English
Pages (from-to)	103-109
Number of pages	7
Journal	Brain Research
Volume	966
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(02)04203-8
Publication status	Published - 2003 Mar 14
Externally published	Yes

Keywords

Brown adipose tissue
Periaqueductal gray
Ventromedial hypothalamic nucleus

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(02)04203-8

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title = "Involvement of the raph{\'e} pallidus in the suppressive effect of preoptic warming on non-shivering thermogenesis in rats",

abstract = "Thermogenesis in the brown adipose tissue (BAT) is activated by the stimulation of the ventromedial hypothalamic nucleus (VMH). Local warming of the preoptic area (PO) suppresses this response. Injection of the GABAA receptor antagonist bicuculline into the caudal periaqueductal gray (cPAG), where excitatory neurons for BAT thermogenesis are located, did not influence the suppressive effect of PO warming. On the other hand, after bicuculline injection into the raph{\'e} pallidus, where excitatory neurons for BAT thermogenesis are also located, VMH stimulation produced BAT thermogenesis even during PO warming. The present results suggest that the inhibitory signal from the PO reaches the raph{\'e} pallidus and not the cPAG for the control of BAT thermogenesis.",

keywords = "Brown adipose tissue, Periaqueductal gray, Ventromedial hypothalamic nucleus",

author = "Aki Taniguchi and Chen, {Xiao Ming} and Kei Nagashima and Mutsumi Tanaka and Kazuyuki Kanosue",

note = "Funding Information: This study was supported by grants-in-aid for scientific research from the Ministry of Education, Science, Sports and Culture of Japan (Grant No. 12307001).",

year = "2003",

month = mar,

day = "14",

doi = "10.1016/S0006-8993(02)04203-8",

language = "English",

volume = "966",

pages = "103--109",

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TY - JOUR

T1 - Involvement of the raphé pallidus in the suppressive effect of preoptic warming on non-shivering thermogenesis in rats

AU - Taniguchi, Aki

AU - Chen, Xiao Ming

AU - Nagashima, Kei

AU - Tanaka, Mutsumi

AU - Kanosue, Kazuyuki

N1 - Funding Information: This study was supported by grants-in-aid for scientific research from the Ministry of Education, Science, Sports and Culture of Japan (Grant No. 12307001).

PY - 2003/3/14

Y1 - 2003/3/14

N2 - Thermogenesis in the brown adipose tissue (BAT) is activated by the stimulation of the ventromedial hypothalamic nucleus (VMH). Local warming of the preoptic area (PO) suppresses this response. Injection of the GABAA receptor antagonist bicuculline into the caudal periaqueductal gray (cPAG), where excitatory neurons for BAT thermogenesis are located, did not influence the suppressive effect of PO warming. On the other hand, after bicuculline injection into the raphé pallidus, where excitatory neurons for BAT thermogenesis are also located, VMH stimulation produced BAT thermogenesis even during PO warming. The present results suggest that the inhibitory signal from the PO reaches the raphé pallidus and not the cPAG for the control of BAT thermogenesis.

AB - Thermogenesis in the brown adipose tissue (BAT) is activated by the stimulation of the ventromedial hypothalamic nucleus (VMH). Local warming of the preoptic area (PO) suppresses this response. Injection of the GABAA receptor antagonist bicuculline into the caudal periaqueductal gray (cPAG), where excitatory neurons for BAT thermogenesis are located, did not influence the suppressive effect of PO warming. On the other hand, after bicuculline injection into the raphé pallidus, where excitatory neurons for BAT thermogenesis are also located, VMH stimulation produced BAT thermogenesis even during PO warming. The present results suggest that the inhibitory signal from the PO reaches the raphé pallidus and not the cPAG for the control of BAT thermogenesis.

KW - Brown adipose tissue

KW - Periaqueductal gray

KW - Ventromedial hypothalamic nucleus

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SN - 0006-8993

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JO - Brain Research

JF - Brain Research

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ER -

Involvement of the raphé pallidus in the suppressive effect of preoptic warming on non-shivering thermogenesis in rats

Abstract

Keywords

ASJC Scopus subject areas

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