Involvement of the raphé pallidus in the suppressive effect of preoptic warming on non-shivering thermogenesis in rats

Aki Taniguchi, Xiao Ming Chen, Kei Nagashima, Mutsumi Tanaka, Kazuyuki Kanosue

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Thermogenesis in the brown adipose tissue (BAT) is activated by the stimulation of the ventromedial hypothalamic nucleus (VMH). Local warming of the preoptic area (PO) suppresses this response. Injection of the GABAA receptor antagonist bicuculline into the caudal periaqueductal gray (cPAG), where excitatory neurons for BAT thermogenesis are located, did not influence the suppressive effect of PO warming. On the other hand, after bicuculline injection into the raphé pallidus, where excitatory neurons for BAT thermogenesis are also located, VMH stimulation produced BAT thermogenesis even during PO warming. The present results suggest that the inhibitory signal from the PO reaches the raphé pallidus and not the cPAG for the control of BAT thermogenesis.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalBrain Research
Volume966
Issue number1
DOIs
Publication statusPublished - 2003 Mar 14
Externally publishedYes

Fingerprint

Brown Adipose Tissue
Thermogenesis
Preoptic Area
Ventromedial Hypothalamic Nucleus
Periaqueductal Gray
Bicuculline
GABA-A Receptor Antagonists
Neurons
Injections

Keywords

  • Brown adipose tissue
  • Periaqueductal gray
  • Ventromedial hypothalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Involvement of the raphé pallidus in the suppressive effect of preoptic warming on non-shivering thermogenesis in rats. / Taniguchi, Aki; Chen, Xiao Ming; Nagashima, Kei; Tanaka, Mutsumi; Kanosue, Kazuyuki.

In: Brain Research, Vol. 966, No. 1, 14.03.2003, p. 103-109.

Research output: Contribution to journalArticle

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AU - Kanosue, Kazuyuki

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