Ionic responsiveness in third ventricular hypertonic stimulation of antidiuresis in ducks

Kazuyuki Kanosue, Rüdiger Gerstberger, Christa Simon-Oppermann, Eckhart Simon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Domestic ducks were chronically equipped with a device probing the third cerebral ventricle (VIII) for localized intracerebroventricular (i.c.v.) perfusion. In conscious animals made diuretic by intravenous water loading with 1.0 ml/min hypoosmotic glucose solution (200 mOsm/kg), hyperosmotic i.c.v. stimulations were tested for antidiuretic actions. Artificial cerebrospinal fluid made hypertonic (400 mOsm/kg) by adding sucrose, mannitol, NaCl, LiCl, choline chloride, NaI, NaNO3, LiNO3, CaCl2 or MgCl2 was perfused i.c.v. for 10-15 min at rates of 10-15 μl/min. Arterial pressure and heart rate were monitored continuously. Hyperosmotic stimulations with non-electrolytes did not induce antidiuresis. Approximately equivalent degrees of antidiuresis were elicited by Na+-, Li+- and choline salts with a tendency for moderate rises in arterial pressure. Compared to Cl-- and I--salts, the effects of NO3--salts were attenuated. Divalent cations caused prolonged antidiuresis, sometimes preceded by initial diuresis, with circulatory side effects unrelated to the changes in renal fluid excretion. It is concluded that the observed antidiuretic effects were mediated by cation-sensitive, rather than osmosensitive neurons on the brain side of the blood-brain-barrier. Their transduction mechanism might consist of poorly selective membrane channels permeable to cations but not to anions.

Original languageEnglish
Pages (from-to)268-274
Number of pages7
JournalBrain Research
Volume569
Issue number2
DOIs
Publication statusPublished - 1992 Jan 13
Externally publishedYes

Keywords

  • Anterior third ventricle
  • Avian osmoregulation
  • Cerebral osmoreception
  • Sodium sensor
  • Urine formation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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