Ir(I)-catalyzed C-H bond alkylation of C2-position of indole with alkenes: Selective synthesis of linear or branched 2-alkylindoles

Shiguang Pan, Naoto Ryu, Takanori Shibata

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

A cationic iridium-catalyzed C2-alkylation of N-substituted indole derivatives with various alkenes has been developed, which selectively gives linear or branched 2-alkylindoles in high to excellent selectivity. This protocol relies on the use of the carbonyl group on the nitrogen atom of indole as a directing group: a linear product was predominant when an acetyl group was used as a directing group, and a branched product was predominant with a benzoyl group.

Original languageEnglish
Pages (from-to)17474-17477
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number42
DOIs
Publication statusPublished - 2012 Oct 24

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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