A cationic iridium-catalyzed C2-alkylation of N-substituted indole derivatives with various alkenes has been developed, which selectively gives linear or branched 2-alkylindoles in high to excellent selectivity. This protocol relies on the use of the carbonyl group on the nitrogen atom of indole as a directing group: a linear product was predominant when an acetyl group was used as a directing group, and a branched product was predominant with a benzoyl group.
|Number of pages||4|
|Journal||Journal of the American Chemical Society|
|Publication status||Published - 2012 Oct 24|
ASJC Scopus subject areas
- Colloid and Surface Chemistry