Ir(I)-catalyzed enantioselective secondary sp 3 C-H bond activation of 2-(alkylamino)pyridines with alkenes

Shiguang Pan, Kohei Endo, Takanori Shibata

Research output: Contribution to journalArticlepeer-review

119 Citations (Scopus)

Abstract

A cationic Ir(I)-tolBINAP complex catalyzed an enantioselective C-C bond formation initiated by secondary sp 3 C-H bond cleavage adjacent to a nitrogen atom. The reaction of 2-(alkylamino)pyridines with various alkenes gave chiral amines in good yields with high enantiomeric excesses.

Original languageEnglish
Pages (from-to)4692-4695
Number of pages4
JournalOrganic Letters
Volume13
Issue number17
DOIs
Publication statusPublished - 2011 Sep 2

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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