Ir(I)-catalyzed enantioselective secondary sp 3 C-H bond activation of 2-(alkylamino)pyridines with alkenes

Shiguang Pan, Kohei Endo, Takanori Shibata

    Research output: Contribution to journalArticle

    111 Citations (Scopus)

    Abstract

    A cationic Ir(I)-tolBINAP complex catalyzed an enantioselective C-C bond formation initiated by secondary sp 3 C-H bond cleavage adjacent to a nitrogen atom. The reaction of 2-(alkylamino)pyridines with various alkenes gave chiral amines in good yields with high enantiomeric excesses.

    Original languageEnglish
    Pages (from-to)4692-4695
    Number of pages4
    JournalOrganic Letters
    Volume13
    Issue number17
    DOIs
    Publication statusPublished - 2011 Sep 2

    Fingerprint

    Pyridines
    Alkenes
    nitrogen atoms
    alkenes
    Amines
    cleavage
    pyridines
    amines
    Nitrogen
    Chemical activation
    activation
    Atoms

    ASJC Scopus subject areas

    • Organic Chemistry
    • Physical and Theoretical Chemistry
    • Biochemistry

    Cite this

    Ir(I)-catalyzed enantioselective secondary sp 3 C-H bond activation of 2-(alkylamino)pyridines with alkenes. / Pan, Shiguang; Endo, Kohei; Shibata, Takanori.

    In: Organic Letters, Vol. 13, No. 17, 02.09.2011, p. 4692-4695.

    Research output: Contribution to journalArticle

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