Ir(I)-catalyzed synthesis of N-substituted pyridones from 2-alkoxypyridines via C-O bond cleavage

Shiguang Pan, Naoto Ryu, Takanori Shibata

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19 Citations (Scopus)

Abstract

A cationic Ir(I) complex-catalyzed O-to-N-alkyl migration in 2-alkoxypyridines bearing a secondary alkyl group on the oxygen atom by C-O bond cleavage is described. The present transformation gave various N-alkylpyridones in moderate to good yields. The addition of sodium acetate played a key role in suppressing β-hydrogen elimination.

Original languageEnglish
Pages (from-to)1902-1905
Number of pages4
JournalOrganic Letters
Volume15
Issue number8
DOIs
Publication statusPublished - 2013 Apr 19

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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