Iridium-catalyzed enantioselective [2 + 2 + 2] cycloaddition of diynes and monoalkynes for the generation of axial chiralities

Takanori Shibata, Yoshikazu Arai, Kyoko Takami, Kyoji Tsuchikama, Takayoshi Fujimoto, Satoshi Takebayashi, Kentaro Takagi

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A highly enantioselective intermolecular [2 + 2 + 2] cycloaddition of alkynes was catalyzed by a chiral iridium complex. Symmetrical and unsymmetrical diynes, and monoalkynes possessing functional group(s) were subjected to the reaction and various types of axially chiral compounds possessing biaryl skeletons were obtained in good to excellent enantiomeric excesses.

Original languageEnglish
Pages (from-to)2475-2483
Number of pages9
JournalAdvanced Synthesis and Catalysis
Volume348
Issue number16-17
DOIs
Publication statusPublished - 2006 Nov 1

Keywords

  • Asymmetric catalysis
  • Chirality
  • Cycloaddition
  • Enantioselectivity
  • Iridium

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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