Iridium-catalyzed enantioselective C-H alkylation of ferrocenes with alkenes using chiral diene ligands

Takanori Shibata, Tsubasa Shizuno

    Research output: Contribution to journalArticle

    113 Citations (Scopus)

    Abstract

    The first catalytic and enantioselective C-H alkylation of ferrocene derivatives with various alkenes was achieved. A cationic iridium complex, having a chiral diene ligand, and an isoquinolyl moiety as a directing group are essential for regioselective and enantioselective C-H bond activation. Director's cut: The first catalytic and enantioselective C-H alkylation of ferrocene derivatives with various alkenes was achieved. A cationic iridium complex, having a chiral diene ligand, and an isoquinolyl moiety as a directing group are essential for regioselective and enantioselective C-H bond activation. coe=cyclooctene, NaBARF=sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate.

    Original languageEnglish
    Pages (from-to)5410-5413
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume53
    Issue number21
    DOIs
    Publication statusPublished - 2014 May 19

    Fingerprint

    Iridium
    Alkylation
    Alkenes
    Olefins
    Chemical activation
    Ligands
    Derivatives
    Sodium
    ferrocene
    tetrakis(3,5-bis(trifluoromethyl)phenyl)borate
    Borates

    Keywords

    • alkylation
    • C-H activation
    • enantioselectivity
    • iridium
    • synthetic methods

    ASJC Scopus subject areas

    • Chemistry(all)
    • Catalysis

    Cite this

    Iridium-catalyzed enantioselective C-H alkylation of ferrocenes with alkenes using chiral diene ligands. / Shibata, Takanori; Shizuno, Tsubasa.

    In: Angewandte Chemie - International Edition, Vol. 53, No. 21, 19.05.2014, p. 5410-5413.

    Research output: Contribution to journalArticle

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