Iridium-catalyzed enantioselective C-H alkylation of ferrocenes with alkenes using chiral diene ligands

Takanori Shibata, Tsubasa Shizuno

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

The first catalytic and enantioselective C-H alkylation of ferrocene derivatives with various alkenes was achieved. A cationic iridium complex, having a chiral diene ligand, and an isoquinolyl moiety as a directing group are essential for regioselective and enantioselective C-H bond activation. Director's cut: The first catalytic and enantioselective C-H alkylation of ferrocene derivatives with various alkenes was achieved. A cationic iridium complex, having a chiral diene ligand, and an isoquinolyl moiety as a directing group are essential for regioselective and enantioselective C-H bond activation. coe=cyclooctene, NaBARF=sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate.

Original languageEnglish
Pages (from-to)5410-5413
Number of pages4
JournalAngewandte Chemie - International Edition
Volume53
Issue number21
DOIs
Publication statusPublished - 2014 May 19

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Keywords

  • C-H activation
  • alkylation
  • enantioselectivity
  • iridium
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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