Iridium-catalyzed enantioselective cycloisomerization of nitrogen-bridged 1,6-enynes to 3-azabicylo[4.1.0]heptenes

Takanori Shibata, Yuka Kobayashi, Shunsuke Maekawa, Natsuko Toshida, Kentaro Takagi

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

A cationic iridium complex catalyzes a cycloisomerization of nitrogen-bridged 1,6-enynes to give 3-azabicyclo[4.1.0]heptenes in good to high yield. When an iridium-chiral diphosphine complex is used, the reaction proceeds enantiomerically to give chiral cyclopropanes fused by a six-membered ring system.

Original languageEnglish
Pages (from-to)9018-9024
Number of pages7
JournalTetrahedron
Volume61
Issue number38
DOIs
Publication statusPublished - 2005 Sep 19

Keywords

  • Cycloisomerization
  • Cyclopropanes
  • Enantioselective
  • Enynes
  • Iridium

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Iridium-catalyzed enantioselective cycloisomerization of nitrogen-bridged 1,6-enynes to 3-azabicylo[4.1.0]heptenes'. Together they form a unique fingerprint.

  • Cite this