Iridium-catalyzed enantioselective Pauson-Khand-type reaction of 1,6-enynes

Takanori Shibata, Natsuko Toshida, Mitsunori Yamasaki, Shunsuke Maekawa, Kentaro Takagi

    Research output: Contribution to journalArticle

    70 Citations (Scopus)

    Abstract

    Iridium-chiral diphosphine complex catalyzes an enantioselective intramolecular Pauson-Khand-type reaction to give various chiral bicyclic cyclopentenones. The enantioselective reaction proceeds more smoothly and enantioselectively under a lower partial pressure of carbon monoxide. Moreover, aldehyde can be used as a CO source in the enantioselective carbonylative coupling.

    Original languageEnglish
    Pages (from-to)9974-9979
    Number of pages6
    JournalTetrahedron
    Volume61
    Issue number42
    DOIs
    Publication statusPublished - 2005 Oct 17

    Fingerprint

    Iridium
    Carbon Monoxide
    Partial Pressure
    Aldehydes
    Partial pressure
    cyclopentenone

    Keywords

    • Carbonylation
    • Enantioselective
    • Enynes
    • Iridium
    • Pauson-Khand reaction

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    Cite this

    Iridium-catalyzed enantioselective Pauson-Khand-type reaction of 1,6-enynes. / Shibata, Takanori; Toshida, Natsuko; Yamasaki, Mitsunori; Maekawa, Shunsuke; Takagi, Kentaro.

    In: Tetrahedron, Vol. 61, No. 42, 17.10.2005, p. 9974-9979.

    Research output: Contribution to journalArticle

    Shibata, T, Toshida, N, Yamasaki, M, Maekawa, S & Takagi, K 2005, 'Iridium-catalyzed enantioselective Pauson-Khand-type reaction of 1,6-enynes', Tetrahedron, vol. 61, no. 42, pp. 9974-9979. https://doi.org/10.1016/j.tet.2005.08.016
    Shibata, Takanori ; Toshida, Natsuko ; Yamasaki, Mitsunori ; Maekawa, Shunsuke ; Takagi, Kentaro. / Iridium-catalyzed enantioselective Pauson-Khand-type reaction of 1,6-enynes. In: Tetrahedron. 2005 ; Vol. 61, No. 42. pp. 9974-9979.
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    AU - Maekawa, Shunsuke

    AU - Takagi, Kentaro

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