Iridium-catalyzed enantioselective Pauson-Khand-type reaction of 1,6-enynes

Takanori Shibata, Natsuko Toshida, Mitsunori Yamasaki, Shunsuke Maekawa, Kentaro Takagi

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Iridium-chiral diphosphine complex catalyzes an enantioselective intramolecular Pauson-Khand-type reaction to give various chiral bicyclic cyclopentenones. The enantioselective reaction proceeds more smoothly and enantioselectively under a lower partial pressure of carbon monoxide. Moreover, aldehyde can be used as a CO source in the enantioselective carbonylative coupling.

Original languageEnglish
Pages (from-to)9974-9979
Number of pages6
JournalTetrahedron
Volume61
Issue number42
DOIs
Publication statusPublished - 2005 Oct 17

Keywords

  • Carbonylation
  • Enantioselective
  • Enynes
  • Iridium
  • Pauson-Khand reaction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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