Iridium-catalyzed intramolecular enantioselective c-h alkylation at the C-2 position of N-alkenylindoles

Takanori Shibata, Naoto Ryu, Hideaki Takano

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Abstract

    Intramolecular enantioselective alkylation of N-alkenylindoles proceeded via C-H bond cleavage at the C-2 position in the presence of a cationic iridium catalyst with a diphosphine ligand. Aroyl groups at the C-3 position of the indoles operated as effective directing groups, and chiral 1-substituted-2,3-dihydro-1H-pyrrolo[1,2-a]indoles were obtained in high yield with excellent ee.

    Original languageEnglish
    Pages (from-to)1131-1135
    Number of pages5
    JournalAdvanced Synthesis and Catalysis
    Volume357
    Issue number6
    DOIs
    Publication statusPublished - 2015 Apr 13

    Fingerprint

    Indoles
    Iridium
    Alkylation
    Ligands
    Catalysts

    Keywords

    • alkylation
    • C-H activation
    • enantioselectivity
    • indoles
    • iridium catalysts

    ASJC Scopus subject areas

    • Catalysis
    • Organic Chemistry

    Cite this

    Iridium-catalyzed intramolecular enantioselective c-h alkylation at the C-2 position of N-alkenylindoles. / Shibata, Takanori; Ryu, Naoto; Takano, Hideaki.

    In: Advanced Synthesis and Catalysis, Vol. 357, No. 6, 13.04.2015, p. 1131-1135.

    Research output: Contribution to journalArticle

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