Iridium-catalyzed intramolecular enantioselective c-h alkylation at the C-2 position of N-alkenylindoles

Takanori Shibata, Naoto Ryu, Hideaki Takano

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

Intramolecular enantioselective alkylation of N-alkenylindoles proceeded via C-H bond cleavage at the C-2 position in the presence of a cationic iridium catalyst with a diphosphine ligand. Aroyl groups at the C-3 position of the indoles operated as effective directing groups, and chiral 1-substituted-2,3-dihydro-1H-pyrrolo[1,2-a]indoles were obtained in high yield with excellent ee.

Original languageEnglish
Pages (from-to)1131-1135
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume357
Issue number6
DOIs
Publication statusPublished - 2015 Apr 13

Keywords

  • C-H activation
  • alkylation
  • enantioselectivity
  • indoles
  • iridium catalysts

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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