Iridium(I)-catalyzed direct C-H bond alkylation of the C-7 position of indolines with alkenes

Shiguang Pan, Naoto Ryu, Takanori Shibata

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

A cationic iridium-catalyzed C-7 alkylation of N-substituted indoline derivatives with various alkenes has been developed. A variety of 7-alkylindolines were obtained in moderate to high yields. This protocol relies on the use of the carbonyl group on the nitrogen atom of indoline as a directing group and it is potentially applicable to the large-scale synthesis of 7-alkylindoles.

Original languageEnglish
Pages (from-to)929-933
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume356
Issue number5
DOIs
Publication statusPublished - 2014 Mar 24

Keywords

  • C-H functionalization
  • N-substituted indolines
  • alkenes
  • alkylation
  • iridium catalysts

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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