Isolation of 1-methylherbipoline salts of halisulfate-1 and of suvanine as serine protease inhibitors from a marine sponge, Coscinoderma mathewsi

J. Kimura, E. Ishizuka, Youichi Nakao, W. Y. Yoshida, P. J. Scheuer, M. Kelly-Borges

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Bioassay-guided isolation of serine protease inhibitors from a marine sponge, Coscinoderma mathewsi, has yielded 1-methylherbipoline salts of halisulfate-1 and of suvanine. Structures of these compounds were identified by spectroscopic analyses and literature data. Antithrombin and antitrypsin activity was determined.

Original languageEnglish
Pages (from-to)248-250
Number of pages3
JournalJournal of Natural Products
Volume61
Issue number2
DOIs
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Coscinoderma
Serine Proteinase Inhibitors
Antithrombins
Bioassay
Porifera
serine proteinases
proteinase inhibitors
Biological Assay
bioassays
Salts
salts
halisulfate 1
suvanine

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Isolation of 1-methylherbipoline salts of halisulfate-1 and of suvanine as serine protease inhibitors from a marine sponge, Coscinoderma mathewsi. / Kimura, J.; Ishizuka, E.; Nakao, Youichi; Yoshida, W. Y.; Scheuer, P. J.; Kelly-Borges, M.

In: Journal of Natural Products, Vol. 61, No. 2, 1998, p. 248-250.

Research output: Contribution to journalArticle

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AU - Scheuer, P. J.

AU - Kelly-Borges, M.

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