Isolation of 1-methylherbipoline salts of halisulfate-1 and of suvanine as serine protease inhibitors from a marine sponge, Coscinoderma mathewsi

J. Kimura, E. Ishizuka, Y. Nakao, W. Y. Yoshida, P. J. Scheuer, M. Kelly-Borges

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Abstract

Bioassay-guided isolation of serine protease inhibitors from a marine sponge, Coscinoderma mathewsi, has yielded 1-methylherbipoline salts of halisulfate-1 and of suvanine. Structures of these compounds were identified by spectroscopic analyses and literature data. Antithrombin and antitrypsin activity was determined.

Original languageEnglish
Pages (from-to)248-250
Number of pages3
JournalJournal of Natural Products
Volume61
Issue number2
DOIs
Publication statusPublished - 1998 Jan 1

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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