K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.

E. Nakajima, T. Hirano, C. Konaka, N. Ikeda, N. Kawate, Y. Ebihara, H. Kato

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

K-ras mutation in sputum was examined using mutant-allele-specific amplification method among 100 primary lung cancer and 15 non-oncological patients. K-ras mutation was detected in 11 out of 59 adenocarcinoma cases (18.6%), 5 out of 32 squamous cell carcinoma cases (15.6%), 2 out of 4 large cell carcinoma cases (50.0%) and 3 out of 15 non-oncological disease cases (20.0%). In the 18 cases of primary lung cancer K-ras mutation was examined in both sputum and the resected specimen of the primary lesion. In 5 cases K-ras mutation in sputum was detected without K-ras mutation in primary lesion. Therefore, these findings suggested that K-ras mutation in sputum may not be directly related to that of the primary lesion.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalInternational journal of oncology
Volume18
Issue number1
DOIs
Publication statusPublished - 2001 Jan

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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